Korrespondierender Autor

Prof. Dr. Nils-Göran Larsson
Phone:+49 221 478-89771Fax:+49 221 478-97409

Cell Biology . Genetics

Research report 2013 - Max Planck Institute for Biology of Ageing

Shedding light on heredity processes of mitochondrial mutations

Authors

Freyer, Christoph; Cree, Lynsey M.; Mourier, Arnaud; Stewart, James B.; Koolmeister, Camilla; Milenkovic, Dusanka; Wai, Timothy; Hagström, Erik; Chatzidaki, Emmanouella E.; Wiesner, Rudolph; Samuels, David C.; Larsson, Nils-Göran; Chinnery, Patrick F.

Departments

Abteilung Mitochondriale Biologie

Summary
Malfunctioning mitochondria can lead to metabolic disorders in the person affected, since mutations in the mitochondrial DNA (mtDNA) can cause muscle weakness, neurodegenerative diseases, cardiac disorders as well as diabetes, and are also linked to the ageing process. In the study presented here, researchers of the Department for Mitochondrial Biology show that intra-familiar differences in the degree of mutation of the mitochondrial genes are largely established before the mother herself is born.

For the full text, see the German version.

 
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