Wissenschaftliche Publikationen

Thedinga, K.; Herwig, R.: Gradient tree boosting and network propagation for the identification of pan-cancer survival networks. STAR Protocols 3 (2), 101353 (2022)

Thomalla, D.; Beckmann, L.; Grimm , C.; Oliverio, M.; Meder, L.; Herling, C. D.; Nieper, P.; Feldmann, T.; Merkel, O.; Lorsy, E. et al.; da Palma Guerreiro , A.; von Jan, J.; Kisis, I.; Wasserburger, E.; Claasen, J.; Faitschuk-Meyer, E.; Altmüller, J.; Nürnberg, P.; Yang, T.-P.; Lienhard, M.; Herwig, R.; Kreuzer, K.-A.; Pallasch, C. P.; Buettner, R.; Schäfer, S. C.; Hartley, J.; Abken, H.; Peifer, M.; Kashkar, H.; Knittel, G.; Eichhorst , B.; Ullrich, R. T.; Herling, M.; Reinhardt, H. C.; Hallek, M.; Schweiger, M. R.; Frenzel, L. P.: Deregulation and epigenetic modification of BCL2-family genes cause resistance to venetoclax in hematologic malignancies. Blood 2022 (2022)

Hetzel, S.; Mattei, A. L.; Kretzmer, H.; Qu, C.; Chen, X.; Fan, Y.; Wu, G.; Roberts, K. G.; Luger, S.; Litzow, M. et al.; Rowe, J.; Paietta, E.; Stock, W.; Mardis, E. R.; Wilson, R. K.; Downing, J. R.; Mullighan, C. G.; Meissner, A.: Acute lymphoblastic leukemia displays a distinct highly methylated genome. Nature Cancer 2022 (2022)

Real, F. M.; Lao-Pérez, M.; Burgos, M.; Mundlos, S.; Lupiáñez, D. G.; Jiménez, R.; Barrionuevo, F. J.: Cell adhesion and immune response, two main functions altered in the transcriptome of seasonally regressed testes of two mammalian species. Journal of Experimental Zoology Part B-Molecular and Developmental Evolution 2022, 14, S. 1 (2022)

Mattei, A. L.; Bailly, N.; Meissner, A.: DNA methylation: a historical perspective. Trends in Genetics (2022)

Hansmeier, N. R.; Büschlen, I. S.; Behncke, R. Y.; Ulferts, S.; Bisoendial, R.; Hägerling, R.: 3D Visualization of Human Blood Vascular Networks Using Single-Domain Antibodies Directed against Endothelial Cell-Selective Adhesion Molecule (ESAM). International Journal of Molecular Sciences 23 (8), 4369 (2022)

Li, Y.; Chen, S.; Rapakoulia, T.; Kuwahara, H.; Yip, K. Y.; Gao, X.: Deep learning identifies and quantifies recombination hotspot determinants. Bioinformatics 2022, btac234 (2022)

Hudert, C. A.; Adams, L. A.; Alisi, A.; Anstee, Q. M.; Crudele, A.; Draijer, L. G.; Furse, S.; Hengstler, J. G.; Jenkins, B.; Karnebeek, K. et al.; Kelly, D. A.; Koot, B. G.; Koulman, A.; Meierhofer, D.; Melton, P. E.; Mori, T. A.; Snowden, S. G.; van Mourik, I.; Vreugdenhil, A.; Wiegand, S.; Mann, J. P.: Variants in mitochondrial amidoxime reducing component 1 and hydroxysteroid 17-beta dehydrogenase 13 reduce severity of nonalcoholic fatty liver disease in children and suppress fibrotic pathways through distinct mechanisms. Hepatology Communications 2022, 1955 (2022)

Lehrach, H.; Curtis, J.; Lange, B.; Ogilvie, L. A.; Gauss, R.; Steininger, C.; Scholz, E.; Kreck, M.: Proposal of a population wide genome-based testing for Covid-19. Scientific Reports 12, 5618 (2022)

Vuaroqueaux, V.; Musch, A.; Kobelt, D.; Risch, T.; Herrmann, P.; Burock, S.; Peille, A.-L.; Yaspo, M.-L.; Fiebig, H.-H.; Stein, U.: Elevated MACC1 Expression in Colorectal Cancer Is Driven by Chromosomal Instability and Is Associated with Molecular Subtype and Worse Patient Survival. Cancers / Molecular Diversity Preservation International (MDPI) 14 (7), 1749 (2022)

Bergfort, A.; Hilal, T.; Kuropka, B.; Ilik, I. A.; Weber, G.; Aktas, T.; Freund, C.; Wahl, M. C.: The intrinsically disordered TSSC4 protein acts as a helicase inhibitor, placeholder and multi-interaction coordinator during snRNP assembly and recycling. Nucleic Acids Research (London) 50 (5), S. 2938 - 2958 (2022)

Hochmair, J.; Exner, C.; Franck, M.; Dominguez-Baquero, A.; Diez, L.; Brognaro, H.; Kraushar, M.; Mielke, T.; Radbruch, H.; Kaniyappan, S. et al.; Falke, S.; Mandelkow, E.; Betzel, C.; Wegmann, S.: Molecular crowding and RNA synergize to promote phase separation, microtubule interaction, and seeding of Tau condensates. The EMBO Journal 2022, e108882 (2022)

Aktas, T.: Transposons: catch them if you can. Nature Reviews Molecular Cell Biology 23, 306 (2022)

Zywitza, V.; Rusha, E.; Shaposhnikov, D.; Ruiz-Orera, J.; Telugu, N.; Rishko, V.; Hayashi, M.; Michel, G.; Wittler, L.; Stejskal, J. et al.; Holtze, S.; Göritz, F.; Hermes, R.; Wang, J.; Izsvák, Z.; Colleoni, S.; Lazzari, G.; Galli, C.; Hildebrandt, T. B.; Hayashi, K.; Diecke, S.; Drukker, M.: Naïve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction. Scientific Reports 12, 3100 (2022)

Gralinska, E.; Kohl, C.; Fadakar, S.; Vingron, M.: Visualizing Cluster-specific Genes from Single-cell Transcriptomics Data Using Association Plots. Journal of Molecular Biology, 167525 (2022)

Bergfort, A.; Preußner, M.; Kuropka, B.; Ilik, I. A.; Hilal, T.; Weber, G.; Freund, C.; Aktas, T.; Heyd, F.; Wahl, M. C.: A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing. Nature Communications 13, 1132 (2022) (2022)

Hertzberg, J.; Mundlos, S.; Vingron, M.; Gallone, G.: TADA – a Machine Learning Tool for Functional Annotation based Prioritisation of Putative Pathogenic CNVs. Genome Biology 23, 67 (2022)

Lybaek, H.; Robson, M.; de Leeuw, N.; Hehir-Kwa, J. Y.; Jeffries, A.; Haukanes, B. I.; Berland, S.; de Bruijn, D.; Mundlos, S.; Spielmann, M. et al.; Houge, G.: LRFN5 locus structure is associated with autism and influenced by the sex of the individual and locus conversions. Autism Research 15 (3), S. 421 - 433 (2022)

Ropers, H.-H.; van Karnebeek, C. D.: Rare diseases: human genome research is coming home. Cold Spring Harbor Molecular Case Studies 8, a006210 (2022)

Ly, L.-H.; Vingron, M.: Effect of imputation on gene network reconstruction from single-cell RNA-seq data. Patterns 3, 100414 (2022)