Scientific Publications

Heyder, N. A.; Kleinau, G.; Speck, D.; Schmidt, A.; Paisdzior, S.; Szczepek, M.; Bauer, B.; Koch, A.; Gallandi, M.; Kwiatkowski, D. et al.; Bürger, J.; Mielke, T.; Beck-Sickinger, A. G.; Hildebrand, P. W.; Spahn, C. M. T.; Hilger, D.; Schacherl, M.; Biebermann, H.; Hilal, T.; Kühnen, P.; Kobilka, B. K.; Scheerer, P.: Structures of active melanocortin-4 receptor−Gs-protein complexes with NDP-α-MSH and setmelanotide. Cell Research, 0:1–14 (2021)

Gu, H.; Raman, A. T.; Wang, X.; Gaiti, F.; Chaligne, R.; Mohammad, A. W.; Arczewska, A. A.; Smith, Z. D.; Landau, D. A.; Aryee, M. J. et al.; Meissner, A.; Gnirke, A.: Smart-RRBS for single-cell methylome and transcriptome analysis. Nature Protocols 16, pp. 4004 - 4030 (2021)

Yagi , M.; Ji, F.; Charlton, J.; Cristea, S.; Messemer, K.; Horwitz, N.; Di Stefano, B.; Tsopoulidis, N.; Hoetker, M. S.; Huebner, A. J. et al.; Bar-Nur, O.; Almada, A. E.; Yamamoto, M.; Patelunas, A.; Goldhamer, D. J.; Wagers, A. J.; Michor, F.; Meissner, A.; Sadreyev, R. I.; Hochedlinger, K.: Dissecting dual roles of MyoD during lineage conversion to mature myocytes and myogenic stem cells. Genes and Development 35 (17-18), pp. 1209 - 1228 (2021)

Li, Y.; Lee, H.; Heo, W. D.; Zi, Z.: Revisiting the Role of TGFβ Receptor Internalization for Smad Signaling: It is Not Required in Optogenetic TGFβ Signaling Systems. Advanced Biology, 2101008 (2021)

Loyal, L.; Braun, J.; Henze, L.; Kruse, B.; Dingeldey, M.; Reimer, U.; Kern, F.; Schwarz, T.; Mangold, M.; Unger, C. et al.; Dörfler, F.; Kadler, S.; Rosowski, J.; Gürcan, K.; Uyar-Aydin, Z.; Frentsch, M.; Kurth, F.; Schnatbaum, K.; Eckey, M.; Hippenstiel, S.; Hocke, A.; Müller, M. A.; Sawitzki, B.; Miltenyi, S.; Friedemann, P.; Mall, M. A.; Wenschuh, H.; Voigt, S.; Drosten, C.; Lauster, R.; Lachman, N.; Sander , L.-E.; Corman, V. M.; Röhmel, J.; Meyer-Arndt, L.; Thiel, A.; Giesecke-Thiel, C.: Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination. Science (2021)

Pacholewska, A.; Grimm, C.; Herling, C. D.; Lienhard, M.; Königs, A.; Timmermann, B.; Altmüller, J.; Mücke, O.; Reinhardt, H. C.; Plass, C. et al.; Herwig, R.; Hallek, M.; Schweiger, M. R.: Altered DNA Methylation Profiles in SF3B1 Mutated CLL Patients. International Journal of Molecular Sciences 22 (17), 9337 (2021)

Jiao, L.; Eickhoff, R.; Egners, A.; Jumpertz , S.; Roth, J.; Erdem, M.; Kroh, A.; Duimel, H.; López-Iglesias, C.; Caro, P. et al.; Heij, L. R.; Schmeding, M.; Meierhofer, D.; Neumann, U. P. ..; Cramer, T.: Deletion of mTOR in liver epithelial cells enhances hepatic metastasis of colon cancer. The Journal of Pathology: an Official Journal of the Pathological Society of Great Britain and Ireland, 5768 (2021)

Huang, Y.-H.; Chen, C.-W.; Sundaramurthy, V.; Słabicki, M.; Hao, D.; Watson, C. J.; Tovy, A.; Reyes, J. M.; Dakhova, O.; Crovetti, B. R. et al.; Galonska, C.; Lee, M.; Brunetti, L.; Zhou, Y.; Tatton-Brown, K.; Huang, Y.; Cheng, X.; Meissner, A.; Valk, P. J. M.; Van Maldergem, L.; Sanders, M. A.; Blundell, J. R.; Li, W.; Ebert, B. L.; Goodell, M. A.: Systematic profiling of DNMT3A variants reveals protein instability mediated by the DCAF8 E3 ubiquitin ligase adaptor. Cancer Discovery, CD-21-0560 (2021)

Loske, J.; Röhmel, J.; Lukassen, S.; Stricker, S.; Magalhães, V. G.; Liebig, J.; Chua, R. L.; Thürmann, L.; Messingschlager, M.; Seegebarth, A. et al.; Timmermann, B.; Klages, S.; Ralser, M.; Sawitzki, B.; Sander, L. E.; Corman, V. M.; Conrad, C.; Laudi, S.; Binder, M.; Trump, S.; Eils, R.; Mall, M. A.; Lehmann, I.: Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children. Nature Biotechnology (2021)

Skern-Mauritzen, R.; Malde, K.; Eichner, C.; Dondrup, M.; Furmanek, T.; Besnier, F.; Komisarczuk, A. Z.; Nuhn, M.; Dalvin, S.; Edvardsen, R. B. et al.; Klages, S.; Huettel, B.; Stueber, K.; Grotmol, S.; Karlsbakk, E.; Kersey, P.; Leong, J. S.; Glover, K. A.; Reinhardt, R.; Lien, S.; Jonassen, I.; Koop, B. F.; Nilsen, F.: The salmon louse genome: Copepod features and parasitic adaptations. Genomics (2021)

Wu, H.-J.; Landshammer, A.; Stamenova, E. K.; Bolondi, A.; Kretzmer, H.; Meissner, A.; Michor, F.: Topological isolation of developmental regulators in mammalian genomes. Nature Communications 12, 4897 (2021)

Bulut-Karslioglu, A.; Jin, H.; Kim, Y.-K.; Cho, B.; Guzman-Ayala, M.; Williamson, A. J. K.; Hejna, M.; Stötzel, M.; Whetton, A. D.; Song, J. S. et al.; Ramalho-Santos, M.: Chd1 protects genome integrity at promoters to sustain hypertranscription in embryonic stem cells. Nature Communications 12, 4859 (2021)

Banchenko, S.; Krupp, F.; Gotthold, C.; Bürger, J.; Graziadei, A.; O'Reilly, F. J.; Sinn, L.; Ruda, O.; Rappsilber, J.; Spahn , C. M. T. et al.; Mielke, T.; Taylor, I. A. ..; Schwefel, D.: Structural insights into Cullin4-RING ubiquitin ligase remodelling by Vpr from simian immunodeficiency viruses. PLoS Pathogens 17 (8), e1009775 (2021)

Arnold, M.; Bressin, A.; Jasnovidova, O.; Meierhofer, D.; Mayer, A.: A BRD4-mediated elongation control point primes transcribing RNA polymerase II for 3′-processing and termination. Molecular Cell (2021)

Labarde, A.; Jakutyte, L.; Billaudeau, C.; Fauler, B.; López-Sanz, M.; Ponien, P.; Jacquet, E.; Mielke, T.; Ayora, S.; Carballido-López, R. et al.; Tavares, P.: Temporal compartmentalization of viral infection in bacterial cells. Proceedings of the National Academy of Sciences of the United States of America 118 (28), e2018297118 (2021)

Huang, T.-W.; Iyer, A. A.; Manalo, J. M.; Woo, J.; Bosquez Huerta, N. A.; McGovern, M. M.; Schrewe, H.; Pereira, F. A.; Groves, A. K.; Ohlemiller, K. K. et al.; Deneen, B.: Glial-Specific Deletion of Med12 Results in Rapid Hearing Loss via Degradation of the Stria Vascularis. The Journal of Neuroscience (2021)

Abdullaev, E.; Umarova, I. R.; Arndt, P. F.: Modelling segmental duplications in the human genome. BMC Genomics 22, 496 (2021)

Bauer, C.; Herwig, R.; Lienhard, M.; Prasse, P.; Scheffer, T.; Schuchhardt, J.: Large-scale literature mining to assess the relation between anti-cancer drugs and cancer types. Journal of Translational Medicine 19, 19:274 (2021)

Jaworski, P.; Zyla-Uklejewicz, D.; Nowaczyk-Cieszewska, M.; Donczew, R.; Mielke, T.; Weigel, C.; Zawilak-Pawlik, A.: Putative Cooperative ATP-DnaA Binding to Double-Stranded DnaA Box and Single-Stranded DnaA-Trio Motif upon Helicobacter pylori Replication Initiation Complex Assembly. International Journal of Molecular Sciences 22 (12), 6643 (2021)

Haggerty, C.; Kretzmer, H.; Riemenschneider, C.; Sampath Kumar, A.; Mattei, A. L.; Bailly, N.; Gottfreund, J.; Giesselmann, P.; Weigert, R.; Brändl, B. et al.; Giehr, P.; Buschow, R.; Galonska, C.; von Meyenn, F.; Pappalardi, M. B.; McCabe, M. T.; Wittler, L.; Giesecke-Thiel, C.; Mielke, T.; Meierhofer, D.; Timmermann, B.; Müller, F.-J.; Walter, J.; Meissner, A.: Dnmt1 has de novo activity targeted to transposable elements. Nature Structural and Molecular Biology 2021 (2021)