Immunobiology

The human immune system is a complex interaction of a multitude of cells, messenger substances and proteins. Numerous molecular biological processes are constantly taking place in our bodies to ensure that parasites and dangerous pathogens cannot cause any damage. Some of these signalling pathways are already well understood, but scientists are still largely in the dark about others. That is why researchers are working hard to better understand the immune system in order to develop more effective protective mechanisms or therapies against harmful organisms. At Max Planck, the Max Planck Institute of Immunobiology and Epigenetics in Freiburg is primarily responsible for this. But immunobiological or immunological research is also carried out at other MPIs, such as the MPI for Biophysics or the MPI for Colloids and Interfaces.

Selective autophagy acts as an immune “fine-tuner” in virus-infected plants

Models and longitudinal data on adherence to nonpharmaceutical interventions need to come together

Discovery points to a potential new therapeutic pathway for Alzheimer’s disease

More than 40 million people worldwide are infected with the herpes virus every year. The virus can pose a serious threat to newborns and people with weakened immune systems. Researchers in Hamburg and Göttingen have now generated a mini-antibody that neutralizes a protein essential for the infection

Nutrient competition restricts parasite growth

Healing a broken heart

April 02, 2025

How a vitamin A metabolite could help myocardial infarction patients by modulating blood stem cell activity

GPRC5B binds to the Prostaglandin Receptor and affects the immune response

Blocking plant immune responses gives colonizing bacteria a competitive advantage

Plant fungus directs barley's immune defense against the plant itself

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Selective autophagy acts as an immune “fine-tuner” in virus-infected plants

More than 40 million people worldwide are infected with the herpes virus every year. The virus can pose a serious threat to newborns and people with weakened immune systems. Researchers in Hamburg and Göttingen have now generated a mini-antibody that neutralizes a protein essential for the infection

Plant fungus directs barley's immune defense against the plant itself

A circuit between the brain and gut influences the gut flora and thus regulates the immune system

Mast cells trap and use living neutrophils during allergic reactions

Researchers were able to trace a form of the autoimmune disease lupus back to a single mutation

A messenger molecule keeps dendritic cells together on their patrol through the tissue

Immune cells in the liver control bacteria spreading after major surgery

Max Planck researchers identify epithelial stem cells that control the growth of the thymus at different stages of life

Studies in African killifish reveal how the immune system ages

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Max Planck researchers develop sustainable alternative to the most widely used antibodies and their controversial production in animals

Researchers are deciphering the structure of the MHC-I peptide-loading complex.

Genetically modified mice deliver first indication that human intestinal bacteria can trigger multiple sclerosis

Max Planck researchers prove that we inherit more than just genes

Obesity alters a subpopulation of immune cells, thereby increasing the risk of developing type 2 diabetes

An enzyme keeps the parasites of the genome in check and turns them into an evolutionary advantage

Obesity can sometimes be shut down

Bats frequently come into contact with infectious diseases, but surprisingly rarely suffer from them

A single factor can reset the immune system of mice to a state likely similar to what it was 500 million years ago, when the first vertebrates emerged.

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Immune System

Video August 17, 2017

The lamprey is a special case amongst vertebrates because it has no thymus gland, where the T cells of the immune system normally learn to recognize pathogens. Max Planck scientist Thomas Böhm wants to know how the lamprey copes with bacteria and viruses. This knowledge could help to improve the treatment of immune disorders in the future.

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