Max Planck Institute of Biochemistry

Max Planck Institute of Biochemistry

Proteins are the molecular building blocks and engines of the cell, and are involved in practically all life processes. Researchers at the Max Planck Institute of Biochemistry investigate the structure of these proteins and how they function – from individual molecules through to complex organisms. They make use of the latest biochemical, imaging and genetic engineering methods to discover the structure of proteins, their properties and the tasks they perform in the human body. Further important areas of research are signal processing and transmission, the regulation of protein breakdown and how cancer evolves. The researchers also want to find out what the actual protein composition of the cell looks like and how complete biological systems function.

Contact

Am Klopferspitz 18
82152 Martinsried
Phone: +49 89 8578-1
Fax: +49 89 8578-3777

PhD opportunities

This institute has an International Max Planck Research School (IMPRS):

IMPRS for Molecular and Cellular Life Sciences: From Biology to Medicine

In addition, there is the possibility of individual doctoral research. Please contact the directors or research group leaders at the Institute.

Department Molecular Structural Biology

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Department Structural Cell Biology

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Department Proteomics and Signal Transduction

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Department Molecular Machines and Signaling

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Department Cellular and Molecular Biophysics

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Six Max Planck researchers land lucrative EU funding

ERC awards Advanced Grants worth up to 2.5 million euros each.

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Proteome of the human heart mapped for the first time

Researchers identify almost 11,000 different proteins throughout the heart

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Cellular power outage

Scientists are discovering pathways for proteins that lead defective proteins to the mitochondria for quality control

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Intestinal flora from twins is able to initiate multiple sclerosis

Genetically modified mice deliver first indication that human intestinal bacteria can trigger multiple sclerosis

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Protein atlas of fly cells

Researchers visualize over 10,000 proteins of Drosophila

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In the Bible, the universe was created step by step: first light, then water and land, and finally the terrestrial animals and humankind. However, from a scientific viewpoint, it seems that the building blocks of life might not have come into being successively, but rather at the same time – at least, this is what Hannes Mutschler of the Max Planck Institute of Biochemistry believes. He and his colleagues in Martinsried, near Munich, are researching the role played by RNA molecules in the emergence of life.

Some time around four billion years ago, life started to become encapsulated. The first cells emerged – protected spaces that facilitated the bonding of complex molecules. Petra Schwille from the Max Planck Institute of Biochemistry in Martinsried and Rumiana Dimova from the Max Planck Institute of Colloids and Interfaces in Potsdam are exploring the boundaries of cellular life. The two researchers are investigating the dynamics of biomembranes.

Elena Conti used to entertain the notion of becoming an architect. The fact that she decided to study chemistry in the end detracted nothing from her passion for the subject. As Director at the Max Planck Institute of Biochemistry in Martinsried, she studies the architecture of molecular machines in the cell – and is fascinated by the sophisticated structures in miniature.

The discovery of a visual pigment in the cell membrane of an archaebacterium in the early 1970s is owed solely to a researcher’s curiosity: For three years, the scientific community wouldn’t believe Dieter Oesterhelt. Forty years after his pioneering work at the Max Planck Institute of Biochemistry in Martinsried, bacteriorhodopsin and channelrhodopsin, which stems from a single-celled green alga, are gaining ground as new tools in neurobiology.

In the course of evolution, cells have acquired a lot of redundancy. Many processes are probably more complicated than they need to be. Petra Schwille from the Max Planck Institute of Biochemistry in Martinsried wants to find out what constitutes the bare essentials of a cell. By concentrating on what’s important, the biophysicist also manages to reconcile her career and family life.

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Oxeiptosis – a ROS induced caspase-independent apoptosis-like cell death pathway

2018 Holze, Cathleen; Benda, Christian; Hubel, Philipp; Pennemann, Friederike L.; Pichlmair, Andreas

Cell Biology Genetics Immunobiology Infection Biology

Reactive oxygen species (ROS) are commonly generated during virus infections, but their significance is only partially understood. We identified a cell death pathway, oxeiptosis, regulating cell death and cell survival after exposure to ROS. Manipulation of oxeiptosis impairs ROS - and virus - induced cell death in vitro and causes lung inflammation and tissue injury in influenza A infected mice. Since ROS are commonly generated during physiologic and pathologic situations, we anticipate that oxeiptosis plays a prominent role in attenuating a wide range of diseases.

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Regulation of the second division of meiosis

2017 Zachariae, Wolfgang

Cell Biology Genetics Structural Biology

Haploid gametes are produced in meiosis, a special form of cell division where DNA replication is followed by two rounds of chromosome segregation and gametogenesis. Homologous chromosomes segregate in meiosis I, whereas chromatids disjoin in meiosis II. Scientists of the research group Chromosome Biology now revealed how the conserved Hrr25 kinase of yeast coordinates production and packaging into gametes of the single-copy genome in meiosis II.

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Getting chromosomes into shape using rings and sticks

2017 Gruber, Stephan

Cell Biology Genetics Structural Biology

Faithful distribution of the genetic material during cell division relies on the folding of DNA into discrete and compact bodies called chromatids. SMC protein complexes have evolved to deal with the tangly nature of long DNA molecules. They act as molecular clamps that bring together selected DNA segments. The researchers determined the architecture of the ancestral SMC complex and elucidated its dynamic localization on the bacterial chromosome. The results indicate that SMC rings are not merely DNA linkers but active machines, which step-by-step enlarge DNA loops to organize chromosomes.

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Autophagy: the multifunctional recycling system of the cell

2016 Kaufmann, Anna; Wollert, Thomas

Cell Biology Genetics Immunobiology Structural Biology

Autophagy is a recycling system of the cell that prevents all kinds of cellular waste from accumulating. Autophagy sequesters such material in specialized containers, which are like other organelles of the cell surrounded by a flexible membrane. These containers transport their contents to cellular recycling stations for degradation. The researchers recently identified a specialized set of proteins that stabilize autophagic containers. Similar to recycling bins, these proteins form a stiff shell on top of the membrane to provide physical support.

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Minimization of life processes

2016 Schwille, Petra

Cell Biology Developmental Biology Evolutionary Biology Genetics Immunobiology Infection Biology Medicine Structural Biology

In spite of the great progress of the biosciences during the last decades, the very line of division between the animate and inanimate world still remains elusive. One of the most distinctive features of living systems is their compositional and organizational complexity, but how complex does life really have to be? Our research aims to identify a minimal set of fundamental features and governing principles of biological cells - being the smallest units of life - to enable their comprehensive biophysical, i.e., quantitative characterization by a defined set of parameters.

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