Max Planck Institute of Biochemistry

Max Planck Institute of Biochemistry

Proteins are the molecular building blocks and engines of the cell, and are involved in practically all life processes. Researchers at the Max Planck Institute of Biochemistry investigate the structure of these proteins and how they function – from individual molecules through to complex organisms. They make use of the latest biochemical, imaging and genetic engineering methods to discover the structure of proteins, their properties and the tasks they perform in the human body. Further important areas of research are signal processing and transmission, the regulation of protein breakdown and how cancer evolves. The researchers also want to find out what the actual protein composition of the cell looks like and how complete biological systems function.

Contact

Am Klopferspitz 18
82152 Martinsried
Phone: +49 89 8578-1
Fax: +49 89 8578-3777

PhD opportunities

This institute has an International Max Planck Research School (IMPRS):

IMPRS for Molecular Life Sciences: From Biological Structures to Neural Circuits

In addition, there is the possibility of individual doctoral research. Please contact the directors or research group leaders at the Institute.

Department Machine learning and systems biology

more

Department Cell and Virus Structure

more

Department Structural Cell Biology

more

Department Proteomics and Signal Transduction

more

Department Molecular Machines and Signaling

more

Department Cellular and Molecular Biophysics

more

Research team achieves Ångström resolution using DNA-barcoded fluorescence microscopy

more

Scientists decipher a mechanism that may help prevent the formation of blood clots

more
Composite image of the Max Planck researchers who were awarded an ERC Advanced Grant 2023. From left to right: Brenda A. Schulman, MPI of Biochemistry, Sven Sturm, MPI of Nuclear Physics, Alexander Meissner, MPI of Molecular Genetics and Sami K. Solanki, MPI of Solar System Research.

Four scientists can look forward to additional funding in this year's ERC Advanced Grants

more

Max Planck scientist and Ivan Ðikić are jointly awarded for their contributions to the ubiquitin research field

more

Two new international programs for doctoral students start at the Max Planck Institutes in Martinsried and Seewiesen

more
Show more

Talking with friends, enjoying a concert, talking on the phone on noisy streets – people with hearing problems are often unable to hear things that others can. Tobias Moser aims to make sound accessible to those with hearing disabilities in a whole new way through a new generation of hearing protheses. Known as optical cochlear implants, these devices serve as an example of therapies developed on the basis of fundamental research.

Researcher or entrepreneur – thanks to Axel Ullrich, this is no longer a contradiction for the Max Planck Society: he‘s both. This is proven by countless publications and honors, two cutting-edge cancer drugs, six start-up companies and over 100 patents. Ullrich, a former Director of the Max Planck Institute of Biochemistry in Martinsried has been instrumental in promoting the combination of basic and applied research at the Max Planck Society.

In the Bible, the universe was created step by step: first light, then water and land, and finally the terrestrial animals and humankind. However, from a scientific viewpoint, it seems that the building blocks of life might not have come into being successively, but rather at the same time – at least, this is what Hannes Mutschler of the Max Planck Institute of Biochemistry believes. He and his colleagues in Martinsried, near Munich, are researching the role played by RNA molecules in the emergence of life.

Some time around four billion years ago, life started to become encapsulated. The first cells emerged – protected spaces that facilitated the bonding of complex molecules. Petra Schwille from the Max Planck Institute of Biochemistry in Martinsried and Rumiana Dimova from the Max Planck Institute of Colloids and Interfaces in Potsdam are exploring the boundaries of cellular life. The two researchers are investigating the dynamics of biomembranes.

Elena Conti used to entertain the notion of becoming an architect. The fact that she decided to study chemistry in the end detracted nothing from her passion for the subject. As Director at the Max Planck Institute of Biochemistry in Martinsried, she studies the architecture of molecular machines in the cell – and is fascinated by the sophisticated structures in miniature.

The discovery of a visual pigment in the cell membrane of an archaebacterium in the early 1970s is owed solely to a researcher’s curiosity: For three years, the scientific community wouldn’t believe Dieter Oesterhelt. Forty years after his pioneering work at the Max Planck Institute of Biochemistry in Martinsried, bacteriorhodopsin and channelrhodopsin, which stems from a single-celled green alga, are gaining ground as new tools in neurobiology.

Postdoc Position (m/f/d) | Cell and Virus Structure

Max Planck Institute of Biochemistry, Martinsried May 25, 2023

Postdoctoral Research Scientists (m/f/d) | Immunoregulation

Max Planck Institute of Biochemistry, Martinsried May 23, 2023

Postdoctoral research fellow (f/m/d)

Max Planck Institute of Biochemistry, Martinsried May 12, 2023

Personal Assistant (m/f/d) | Department Molecular Machines and Signaling

Max Planck Institute of Biochemistry, Martinsried May 05, 2023

Measuring the tRNA world by mim-tRNAseq

2021 Behrens, Andrew; Rodschinka, Geraldine; Nedialkova, Danny

Cell Biology Evolutionary Biology Genetics

Transfer RNAs (tRNAs) specifically deliver amino acids to ribosomes during the translation of messenger RNA (mRNA) into proteins. The abundance of tRNAs therefore has a profound impact on cells. However, determining the amount of each tRNA species in cells was limited because of technical challenges. We overcame these limitations thanks to mim-tRNAseq, a method that can be used to quantify tRNAs in any organism and will help improve our understanding of tRNA regulation in health and disease.

more

Genetically reproductive material from the test tube

2020 Libicher, Kai; Hornberger, Renate; Heymann, Michael; Mutschler, Hannes

Cell Biology Genetics Medicine

The field of synthetic biology aims to assemble life-like systems from inanimate building blocks. Our goal is not only to observe and describe processes of life, but also to mimic them. A key characteristic of life is its ability to replicate its own macromolecular components. We have generated a new in vitro system that can regenerate some of its own DNA and protein building blocks.

more

Intercellular contacts - the self-inhibitory mechanism of Talin

2019 Dedden, Dirk; Schumacher, Stephanie; Kelley, Charlotte F.; Zacharias, Martin; Biertümpfel, Christian; Fässler, Reinhard; Mizuno, Naoko

Cell Biology Structural Biology

Cells contact other cells via precise docking points. Cell migration and immune reactions require a finely tuned attachment and detachment process. Therefore, the contact sites consist of a whole machinery of proteins, in which talin plays a central role. Using cryo-electron microscopy, we were able to show how talin can assume an inactive spherical shape and is thus inaccessible to contact other proteins. These results help to understand the adhesion mechanism and also dysfunctions in disease processes.

more

The ability of cells to sense and respond to mechanical signals is central to numerous biological processes. How mechanical signals are processed in cells has remained unclear, because techniques to detect the extremely small molecular forces in cells were missing. We therefore developed a technology that allows quantification of intracellular forces that are as low as a billionth of a newton. First applications reveal fascinating insights into the molecular mechanisms underlying cellular mechanobiology.

more

Oxeiptosis – a ROS induced caspase-independent apoptosis-like cell death pathway

2017 Holze, Cathleen; Benda, Christian; Hubel, Philipp; Pennemann, Friederike L.; Pichlmair, Andreas

Cell Biology Genetics Immunobiology Infection Biology

Reactive oxygen species (ROS) are commonly generated during virus infections, but their significance is only partially understood. We identified a cell death pathway, oxeiptosis, regulating cell death and cell survival after exposure to ROS. Manipulation of oxeiptosis impairs ROS - and virus - induced cell death in vitro and causes lung inflammation and tissue injury in influenza A infected mice. Since ROS are commonly generated during physiologic and pathologic situations, we anticipate that oxeiptosis plays a prominent role in attenuating a wide range of diseases.

more
Go to Editor View