2017, Max Planck Institute for Molecular Genetics
Kinkley, Sarah; Helmuth, Johannes; Chung, Ho-Ryun
Chromatin modifications provide information above the DNA sequence. The modifications correlate with transcriptional activity, constitute a memory of past decisions, and are thought to provide a state that enables future decisions. The direct measurement of a at the end conflicting combination of chromatin modifications revealed that this combination is not a reflection of molecular potential, as has been thought, but is required to dampen the mutation rate within important genes. Hence, chromatin modifications are key players keeping the DNA sequence in shape and thereby influence evolution.