Research report 2018 - Max Planck Institute for Molecular Genetics
Writing DNA methylation in mammalian genomes
Galonska, Christina; Charlton, Jocelyn; Mattei, Alexandra; Meissner, Alexander
SummaryDuring the development of an organism, the sequence of its DNA remains unchanged. Gene activity, however, is epigenetically controlled by reversible modifications of the DNA sequence, such as methylation of cytosines. We are working on the development of a system for targeted methylation of the genome at defined positions. Thus, we hope to gain a comprehensive understanding of the role of DNA methylation for the regulation of gene activity, thereby paving the way for the development of new therapeutic approaches for a range of diseases.