Research report 2021 - Max Planck Institute for Molecular Genetics
X-Chromosome as a model for genetic regulation
Schulz, Edda G.
Lise-Meitner-Gruppenleiterin Systems Epigenetics
SummaryThe inactivation of one of the two X chromosomes in females can not only explain various inheritable diseases, but also allows us to study how the activity of our genome is controlled. X inactivation is governed by the Xist gene, which is able to silence an entire chromosome. Although this process appears to be restricted to mammals, the underlying regulatory mechanisms are used in various contexts of genome regulation.