Scientific Publications

Fernandes, S. A.; Angelidaki, D.-D.; Nuechel, J.; Pan, J.; Gollwitzer, P.; Elkis, Y.; Artoni, F.; Wilhelm, S.; Kovacevic-Sarmiento, M.; Demetriades, C.: Spatial and functional separation of mTORC1 signalling in response to different amino acid sources. Nature Cell Biology (2024)

Jia, X.; Fan, J.; Wu, X.; Cao, X.; Ma, L.; Abdelrahman, Z.; Zhao, F.; Zhu, H.; Bizzarri, D.; Akker, E. B. v. d. et al.; Slagboom, P. E.; Deelen, J.; Zhou, D.; Liu, Z.: A Novel Metabolomic Aging Clock Predicting Health Outcomes and Its Genetic and Modifiable Factors. Advanced Science (2024)

Mukherjee, R.; Bhattacharya, A.; Mello-Vieira, J.; Kuncha, S. K.; Hoffmann, M.; Gonzalez, A.; Rathore, R.; Chadha, A.; Shin, D.; Colby, T. et al.; Matić, I.; Mukherjee, S.; Misra, M.; Dikic, I.: Serine ubiquitination of SQSTM1 regulates NFE2L2-dependent redox homeostasis. Autophagy (2024)

Sawczyc, H.; Tatsuta, T.; Öster, C.; Kosteletos, S.; Lange, S.; Bohg, C.; Langer, T.; Lange, A.: Lipid-polymer nanoparticles to probe the native-like environment of intramembrane rhomboid protease GlpG and its activity. Nature Communications 15, 7533 (2024)

Sittig, J.; Pickert, L.; Weigert, H.; Deelen, J.; Polidori, C. M.; Nelles, G.: Relationship Between Endothelial Function, Vital Parameters, and Cognitive Performance in Community Dwellers with Subjective Cognitive Decline: An Observational Study with Six Months Follow Up. J Alzheimers Dis. (2024)

Aich, A.; Boshnakovska, A.; Witte, S.; Gall, T.; Unthan-Fechner, K.; Yousefi, R.; Chowdhury, A.; Dahal, D.; Methi, A.; Kaufmann, S. et al.; Silbern, I.; Prochazka, J.; Nichtova, Z.; Palkova, M.; Raishbrook, M.; Koubkova, G.; Sedlacek, R.; Tröder, S. E.; Zevnik, B.; Riedel, D.; Michanski, S.; Möbius, W.; Ströbel, P.; Lüchtenborg, C.; Giavalisco, P.; Urlaub, H.; Fischer, A.; Brügger, B.; Jakobs, S.; Rehling, P.: Defective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in mouse liver. Nature Communications 15, 6914 (2024)

Hofer, S. J.; Daskalaki, I.; Bergmann, M.; Friščić, J.; Zimmermann, A.; Mueller, M. I.; Abdellatif, M.; Nicastro, R.; Masser, S.; Durand, S. et al.; Nartey, A.; Waltenstorfer, M.; Enzenhofer, S.; Faimann, I.; Gschiel, V.; Bajaj, T.; Niemeyer, C.; Gkikas, I.; Pein, L.; Cerrato, G.; Pan, H.; Liang, Y.; Tadic, J.; Jerkovic, A.; Aprahamian, F.; Robbins, C. E.; Nirmalathasan, N.; Habisch, H.; Annerer, E.; Dethloff, F.; Stumpe, M.; Grundler, F.; Wilhelmi de Toledo, F.; Heinz, D. E.; Koppold, D. A.; Rajput Khokhar, A.; Michalsen, A.; Tripolt, N. J.; Sourij, H.; Pieber, T. R.; de Cabo, R.; McCormick, M. A.; Magnes, C.; Kepp, O.; Dengjel, J.; Sigrist, S. J.; Gassen, N. C.; Sedej, S.; Madl, T.; De Virgilio, C.; Stelzl, U.; Hoffmann, M. H.; Eisenberg, T.; Tavernarakis, N.; Kroemer, G.; Madeo, F.: Spermidine is essential for fasting-mediated autophagy and longevity. Nature Cell Biology (2024)

Pickert, L.; Dias, I. H. K.; Thimm, A.; Weber, J.; Abdullah, S.; Deelen, J.; Polidori, M. C.: Micronutrients, Frailty, and Cognitive Impairment: Design and Preliminary Results from the CogLife 2.0 Study. Micronutrients, Frailty, and Cognitive Impairment: Design and Preliminary Results from the CogLife 2.0 Study (2024)

Horikawa, M.; Fukuyama, M.; Antebi, A.; Mizunuma, M.: Regulatory mechanism of cold-inducible diapause in Caenorhabditis elegans. Nature Communications 15, 5793 (2024)

Cipullo, M.; Valentín Gesé, G.; Gopalakrishna, S.; Krueger, A.; Lobo, V.; Pirozhkova, M. A.; Marks, J.; Páleníková, P.; Shiriaev, D.; Liu, Y. et al.; Misic, J.; Cai, Y.; Nguyen, M. D.; Abdelbagi, A.; Li, X.; Minczuk, M.; Hafner, M.; Benhalevy, D.; Sarshad, A. A.; Atanassov, I.; Hällberg, B. M.; Rorbach, J.: GTPBP8 plays a role in mitoribosome formation in human mitochondria. Nature Communications 15, 5664 (2024)

van Holstein, Y.; Mooijaart, S. P.; van Oevelen, M.; van Deudekom, F. J.; Vojinovic, D.; Bizzarri, D.; van den Akker, E. B.; Noordam, R.; Deelen, J.; van Heemst, D. et al.; de Glas, N. A.; Holterhues, C.; Labots, G.; van den Bos, F.; Beekman, M.; Slagboom, P. E.; van Munster, B. C.; Portielje, J. E. A.; Trompet, S.: The performance of metabolomics-based prediction scores for mortality in older patients with solid tumors. GeroScience (2024)

Longarini, E. J.; Matić, I.: Preserving ester-linked modifications reveals glutamate and aspartate mono-ADP-ribosylation by PARP1 and its reversal by PARG. Nature Communications 15, 4239 (2024)

Jiang, S.; Yuan, T.; Rosenberger, F. A.; Mourier, A.; Dragano, N. R. V.; Kremer, L. S.; Rubalcava-Gracia, D.; Hansen, F. M.; Borg, M.; Mennuni, M. et al.; Filograna, R.; Alsina, D.; Misic, J.; Koolmeister, C.; Papadea, P.; de Angelis, M. H.; Ren, L.; Andersson, O.; Unger, A.; Bergbrede, T.; Di Lucrezia, R.; Wibom, R.; Zierath, J. R.; Krook, A.; Giavalisco, P.; Mann, M.; Larsson, N.-G.: Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity. Nature Metabolism (2024)

Timofeev, O.; Giron, P.; Lawo, S.; Pichler, M.; Noeparast, M.: ERK pathway agonism for cancer therapy: evidence, insights, and a target discovery framework. npj Precision Oncology 8, 70 (2024)

Zhang, P.; Catterson, J. H.; Grönke, S.; Partridge, L.: Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system. Nature Aging (2024)

De Solis, A. J.; Del Río-Martín, A.; Radermacher, J.; Chen, W.; Steuernagel, L.; Bauder, C. A.; Eggersmann, F. R.; Morgan, D. A.; Cremer, A.-L.; Sué, M. et al.; Germer, M.; Kukat, C.; Vollmar, S.; Backes, H.; Rahmouni, K.; Kloppenburg, P.; Brüning, J. C.: Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism. Nature Metabolism (2024)

Almannai, M.; Marafi, D.; Zaki, M. S.; Maroofian, R.; Efthymiou, S.; Saadi, N. W.; Filimban, B.; Dafsari, H. S.; Rahman, F.; Maqbool, S. et al.; Faqeih, E.; Al Mutairi, F.; Alsharhan, H.; Abdelaty, O.; Bin‐Hasan, S.; Duan, R.; Noureldeen, M. M.; Alqattan, A.; Houlden, H.; Hunter, J. V.; Posey, J. E.; Lupski, J. R.; El‐Hattab, A. W.: Expanding the phenotype ofPPP1R21‐related neurodevelopmental disorder. Clinical Genetics (2024)

Baum, E.; Huang, W.; Vincent-Delorme, C.; Brunelle, P.; Antebi, A.; Dafsari, H. S.: Novel Genetic and Phenotypic Expansion in Ameliorated PUF60-Related Disorders. International Journal of Molecular Sciences 25, p. 2053 (2024)

Gross, A.; Ghillebert, R.; Schuetter, M.; Reinartz, E.; Rowland, A.; Bishop, B. C.; Stumpe, M.; Dengjel, J.; Graef, M.: A metabolite sensor subunit of the Atg1/ULK complex regulates selective autophagy. Nature Cell Biology (2024)

Wang, X.; Jiang, Q.; Zhang, H.; He, Z.; Song, Y.; Chen, Y.; Tang, N.; Zhou, Y.; Li, Y.; Antebi, A. et al.; Wu, L.; Han, J.-D. J.; Shen, Y.: Tissue-specific profiling of age-dependent miRNAomic changes in Caenorhabditis elegans. Nature Communications 15, 955 (2024)