Scientific Publications

Tutas, J.; Tolve, M.; Özer-Yildiz, E.; Ickert, L.; Klein, I.; Silverman, Q.; Liebsch, F.; Dethloff, F.; Giavalisco, P.; Endepols, H. et al.; Georgomanolis, T.; Neumaier, B.; Drzezga, A.; Schwarz, G.; Thorens, B.; Gatto, G.; Frezza, C.; Kononenko, N. L.: Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity. Nature Metabolism (2025)

Perri, G.; French, C.; Agostinis-Sobrinho, C.; Anand, A.; Antarianto, R. D.; Arai, Y.; Baur, J. A.; Cauli, O.; Clivaz-Duc, M.; Colloca, G. et al.; Demetriades, C.; de Lucia, C.; Di Gessa, G.; Diniz, B. S.; Dotchin, C. L.; Eaglestone, G.; Elliott, B. T.; Espeland, M. A.; Ferrucci, L.; Fisher, J.; Grammatopoulos, D. K.; Hardiany, N. S.; Hassan-Smith, Z.; Hastings, W. J.; Jain, S.; Joshi, P. K.; Katsila, T.; Kemp, G. J.; Khaiyat, O. A.; Lamming, D. W.; Gallegos, J. L.; Madeo, F.; Maier, A. B.; Martin-Ruiz, C.; Martins, I. J.; Mathers, J. C.; Mattin, L. R.; Merchant, R. A.; Moskalev, A.; Neytchev, O.; Ni Lochlainn, M.; Owen, C. M.; Phillips, S. M.; Pratt, J.; Prokopidis, K.; Rattray, N. J. W.; Rúa-Alonso, M.; Schomburg, L.; Scott, D.; Shyam, S.; Sillanpää, E.; Tan, M. M. C.; Teh, R.; Tobin, S. W.; Vila-Chã, C. J.; Vorluni, L.; Weber, D.; Welch, A.; Wilson, D.; Wilson, T.; Zhao, T.; Philippou, E.; Korolchuk, V. I.; Shannon, O. M.: An expert consensus statement on biomarkers of ageing for use in intervention studies. The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences (2024)

Müller-Eigner, A.; Gille, B.; Dethloff, F.; Meng, C.; Ludwig, C.; Heiker, J. T.; Giavalisco, P.; Peleg, S.: Sodium butyrate is incorporated into central metabolism in fly head while inducing oxygen consumption increase. PLOS ONE 19, p. e0315892 (2024)

Gladyshev, V. N.; Anderson, B.; Barlit, H.; Barre, B.; Beck, S.; Behrouz, B.; Belsky, D. W.; Chaix, A.; Chamoli, M.; Chen, B. H. et al.; Cheng, K.; Chuprin, J.; Churchill, G. A.; Cipriano, A.; Colville, A.; Deelen, J.; Deigin, Y.; Edmonds, K. K.; English, B. W.; Fang, R.; Florea, M.; Gershteyn, I. M.; Gill, D.; Goetz, L. H.; Gorbunova, V.; Griffin, P. T.; Horvath, S.; Borch Jensen, M.; Jin, X.; Jovanovska, S.; Kajderowicz, K. M.; Kasahara, T.; Kerepesi, C.; Kulkarni, S.; Labunskyy, V. M.; Levine, M. E.; Libert, S.; Lu, J. Y.; Lu, Y. R.; Marioni, R. E.; McCoy, B. M.; Mitchell, W.; Moqri, M.; Nasirian, F.; Niimi, P.; Oh, H. S.; Okundaye, B.; Parkhitko, A. A.; Peshkin, L.; Petljak, M.; Poganik, J. R.; Pridham, G.; Promislow, D. E. L.; Prusisz, W.; Quiniou, M.; Raj, K.; Richard, D.; Ricon, J. L.; Rutledge, J.; Scheibye-Knudsen, M.; Schork, N. J.; Seluanov, A.; Shadpour, M.; Shindyapina, A. V.; Shuken, S. R.; Sivakumar, S.; Stoeger, T.; Sugiura, A.; Sutton, N. R.; Suvorov, A.; Tarkhov, A. E.; Teeling, E. C.; Trapp, A.; Tyshkovskiy, A.; Unfried, M.; Ward-Caviness, C. K.; Yim, S. H.; Ying, K.; Yunes, J.; Zhang, B.; Zhavoronkov, A.: Disagreement on foundational principles of biological aging. PNAS Nexus 3 (12), p. pgae499 (2024)

Kaade, E.; Mausbach, S.; Erps, N.; Sylvester, M.; Shakeri, F.; Jachimowicz, R. D.; Gieselmann, V.; Thelen , M.: Starvation-induced metabolic rewiring affects mTORC1 composition in vivo. Scientific Reports 14, 28296 (2024)

Martins Garcia, B.; Philipp, M.; Medeiros, T. C.; Hendrix, S.; Prabhu , K.; Corrado, M.; Kingma, J.; Gorbatenko, A.; Deshwal, S.; Veronese, M. et al.; Scorrano, L.; Pearce, E.; Giavalisco, P.; Zelcer, N.; Pernas, L.: Glutamine sensing licenses cholesterol synthesis. The EMBO Journal (2024)

Fernandes, S. A.; Angelidaki, D.-D.; Nuechel, J.; Pan, J.; Gollwitzer, P.; Elkis, Y.; Artoni, F.; Wilhelm, S.; Kovacevic-Sarmiento, M.; Demetriades, C.: Spatial and functional separation of mTORC1 signalling in response to different amino acid sources. Nature Cell Biology (2024)

Jia, X.; Fan, J.; Wu, X.; Cao, X.; Ma, L.; Abdelrahman, Z.; Zhao, F.; Zhu, H.; Bizzarri, D.; Akker, E. B. v. d. et al.; Slagboom, P. E.; Deelen, J.; Zhou, D.; Liu, Z.: A Novel Metabolomic Aging Clock Predicting Health Outcomes and Its Genetic and Modifiable Factors. Advanced Science (2024)

Mukherjee, R.; Bhattacharya, A.; Mello-Vieira, J.; Kuncha, S. K.; Hoffmann, M.; Gonzalez, A.; Rathore, R.; Chadha, A.; Shin, D.; Colby, T. et al.; Matić, I.; Mukherjee, S.; Misra, M.; Dikic, I.: Serine ubiquitination of SQSTM1 regulates NFE2L2-dependent redox homeostasis. Autophagy (2024)

Sawczyc, H.; Tatsuta, T.; Öster, C.; Kosteletos, S.; Lange, S.; Bohg, C.; Langer, T.; Lange, A.: Lipid-polymer nanoparticles to probe the native-like environment of intramembrane rhomboid protease GlpG and its activity. Nature Communications 15, 7533 (2024)

Sittig, J.; Pickert, L.; Weigert, H.; Deelen, J.; Polidori, C. M.; Nelles, G.: Relationship Between Endothelial Function, Vital Parameters, and Cognitive Performance in Community Dwellers with Subjective Cognitive Decline: An Observational Study with Six Months Follow Up. J Alzheimers Dis. (2024)

Aich, A.; Boshnakovska, A.; Witte, S.; Gall, T.; Unthan-Fechner, K.; Yousefi, R.; Chowdhury, A.; Dahal, D.; Methi, A.; Kaufmann, S. et al.; Silbern, I.; Prochazka, J.; Nichtova, Z.; Palkova, M.; Raishbrook, M.; Koubkova, G.; Sedlacek, R.; Tröder, S. E.; Zevnik, B.; Riedel, D.; Michanski, S.; Möbius, W.; Ströbel, P.; Lüchtenborg, C.; Giavalisco, P.; Urlaub, H.; Fischer, A.; Brügger, B.; Jakobs, S.; Rehling, P.: Defective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in mouse liver. Nature Communications 15, 6914 (2024)

Hofer, S. J.; Daskalaki, I.; Bergmann, M.; Friščić, J.; Zimmermann, A.; Mueller, M. I.; Abdellatif, M.; Nicastro, R.; Masser, S.; Durand, S. et al.; Nartey, A.; Waltenstorfer, M.; Enzenhofer, S.; Faimann, I.; Gschiel, V.; Bajaj, T.; Niemeyer, C.; Gkikas, I.; Pein, L.; Cerrato, G.; Pan, H.; Liang, Y.; Tadic, J.; Jerkovic, A.; Aprahamian, F.; Robbins, C. E.; Nirmalathasan, N.; Habisch, H.; Annerer, E.; Dethloff, F.; Stumpe, M.; Grundler, F.; Wilhelmi de Toledo, F.; Heinz, D. E.; Koppold, D. A.; Rajput Khokhar, A.; Michalsen, A.; Tripolt, N. J.; Sourij, H.; Pieber, T. R.; de Cabo, R.; McCormick, M. A.; Magnes, C.; Kepp, O.; Dengjel, J.; Sigrist, S. J.; Gassen, N. C.; Sedej, S.; Madl, T.; De Virgilio, C.; Stelzl, U.; Hoffmann, M. H.; Eisenberg, T.; Tavernarakis, N.; Kroemer, G.; Madeo, F.: Spermidine is essential for fasting-mediated autophagy and longevity. Nature Cell Biology (2024)

Pickert, L.; Dias, I. H. K.; Thimm, A.; Weber, J.; Abdullah, S.; Deelen, J.; Polidori, M. C.: Micronutrients, Frailty, and Cognitive Impairment: Design and Preliminary Results from the CogLife 2.0 Study. Micronutrients, Frailty, and Cognitive Impairment: Design and Preliminary Results from the CogLife 2.0 Study (2024)

Horikawa, M.; Fukuyama, M.; Antebi, A.; Mizunuma, M.: Regulatory mechanism of cold-inducible diapause in Caenorhabditis elegans. Nature Communications 15, 5793 (2024)

Cipullo, M.; Valentín Gesé, G.; Gopalakrishna, S.; Krueger, A.; Lobo, V.; Pirozhkova, M. A.; Marks, J.; Páleníková, P.; Shiriaev, D.; Liu, Y. et al.; Misic, J.; Cai, Y.; Nguyen, M. D.; Abdelbagi, A.; Li, X.; Minczuk, M.; Hafner, M.; Benhalevy, D.; Sarshad, A. A.; Atanassov, I.; Hällberg, B. M.; Rorbach, J.: GTPBP8 plays a role in mitoribosome formation in human mitochondria. Nature Communications 15, 5664 (2024)

van Holstein, Y.; Mooijaart, S. P.; van Oevelen, M.; van Deudekom, F. J.; Vojinovic, D.; Bizzarri, D.; van den Akker, E. B.; Noordam, R.; Deelen, J.; van Heemst, D. et al.; de Glas, N. A.; Holterhues, C.; Labots, G.; van den Bos, F.; Beekman, M.; Slagboom, P. E.; van Munster, B. C.; Portielje, J. E. A.; Trompet, S.: The performance of metabolomics-based prediction scores for mortality in older patients with solid tumors. GeroScience (2024)

Longarini, E. J.; Matić, I.: Preserving ester-linked modifications reveals glutamate and aspartate mono-ADP-ribosylation by PARP1 and its reversal by PARG. Nature Communications 15, 4239 (2024)

Jiang, S.; Yuan, T.; Rosenberger, F. A.; Mourier, A.; Dragano, N. R. V.; Kremer, L. S.; Rubalcava-Gracia, D.; Hansen, F. M.; Borg, M.; Mennuni, M. et al.; Filograna, R.; Alsina, D.; Misic, J.; Koolmeister, C.; Papadea, P.; de Angelis, M. H.; Ren, L.; Andersson, O.; Unger, A.; Bergbrede, T.; Di Lucrezia, R.; Wibom, R.; Zierath, J. R.; Krook, A.; Giavalisco, P.; Mann, M.; Larsson, N.-G.: Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity. Nature Metabolism (2024)

Timofeev, O.; Giron, P.; Lawo, S.; Pichler, M.; Noeparast, M.: ERK pathway agonism for cancer therapy: evidence, insights, and a target discovery framework. npj Precision Oncology 8, 70 (2024)