Scientific Publications

Partridge, L.; Fuentealba, M.; Kennedy, B. K.: The Quest to Slow Ageing through Drug Discovery. Nature Reviews Drug Discovery 19, pp. 513 - 532 (2020)

Tain, L. S.; Jain, C.; Nespital, T.; Fröhlich, J.; Hinze, Y.; Grönke, S.; Partridge, L.: Longevity in response to lowered insulin signaling requires glycine N‐methyltransferase‐dependent spermidine production. Aging Cell 19 (1) (2019)

Castillo-Quan, J.; Tain, L. S.; Kinghorn, K. J.; Li, L.; Grönke, S.; Hinze, Y.; Blackwell , T. K.; Bjedov, I.; Partridge, L.: A triple drug combination targeting components of the nutrient-sensing network maximizes longevity. Proceedings of the National Academy of Sciences of the United States of America 116 (42), pp. 20817 - 20819 (2019)

Bacman, S. R.; Kauppila, J. H. K.; Pereira, C. V.; Nissanka, N.; Miranda, M.; Pinto, M.; Williams, S. L.; Larsson, N. G.; Stewart, J. B.; Moraes, C. T.: MitoTALEN reduces mutant mtDNA load and restores tRNA(Ala) levels in a mouse model of heteroplasmic mtDNA mutation. Nat Med 24 (11), pp. 1696 - 1700 (2018)

Gammage, P. A.; Viscomi, C.; Simard, M. L.; Costa, A. S. H.; Gaude, E.; Powell, C. A.; Van Haute, L.; McCann, B. J.; Rebelo-Guiomar, P.; Cerutti, R. et al.; Zhang, L.; Rebar, E. J.; Zeviani, M.; Frezza, C.; Stewart, J. B.; Minczuk, M.: Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo. Nat Med 24 (11), pp. 1691 - 1695 (2018)

Flatt, T.; Partridge, L.: Horizons in the evolution of aging. BMC Biology 16 (2018)

Colby, T.; Bonfiglio, J. J.; Matic, I.: Nonlocalized Searching of HCD Data for Fast and Sensitive Identification of ADP-Ribosylated Peptides. Methods Mol Biol 1813, pp. 255 - 269 (2018)

Seidel, J.; Valenzano, D. R.: The role of the gut microbiome during host ageing. F1000Res 7 (2018)

Dodzian, J.; Kean, S.; Seidel, J.; Valenzano, D. R.: A Protocol for Laboratory Housing of Turquoise Killifish (Nothobranchius furzeri). J Vis Exp (134) (2018)

Saita, S.; Tatsuta, T.; Lampe, P. A.; Konig, T.; Ohba, Y.; Langer, T.: PARL partitions the lipid transfer protein STARD7 between the cytosol and mitochondria. EMBO J (2018)

Annibal, A.; Karalay, o.; Latza, C.; Antebi, A.*.: A novel EI-GC/MS method for the accurate quantification of anti-aging compound oleoylethanolamine in C. elegans. Analytical Methods (22) (2018)

Augustin, H.; McGourty, K.; Allen, M. J.; Adcott, J.; Wong, C. T.; Boucrot, E.; Partridge, L.: Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster. Neurobiol Aging 66, pp. 149 - 157 (2018)

Bartlett, E.; Bonfiglio, J. J.; Prokhorova, E.; Colby, T.; Zobel, F.; Ahel, I.; Matic, I.: Interplay of Histone Marks with Serine ADP-Ribosylation. Cell Rep 24 (13), pp. 3488 - 3502 e5 (2018)

Blank, M. L.; Parker, M. L.; Ramaswamy, R.; Powell, C. J.; English, E. D.; Adomako-Ankomah, Y.; Pernas, L. F.; Workman, S. D.; Boothroyd, J. C.; Boulanger, M. J. et al.; Boyle, J. P.: A Toxoplasma gondii locus required for the direct manipulation of host mitochondria has maintained multiple ancestral functions. Mol Microbiol 108 (5), pp. 519 - 535 (2018)

Brandt, C.; Nolte, H.; Henschke, S.; Engstrom Ruud, L.; Awazawa, M.; Morgan, D. A.; Gabel, P.; Sprenger, H. G.; Hess, M. E.; Gunther, S. et al.; Langer, T.; Rahmouni, K.; Fenselau, H.; Kruger, M.; Bruning, J. C.: Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation. Cell 175 (5), pp. 1321 - 1335 e20 (2018)

Catterson, J. H.; Khericha, M.; Dyson, M. C.; Vincent, A. J.; Callard, R.; Haveron, S. M.; Rajasingam, A.; Ahmad, M.; Partridge, L.: Short-Term, Intermittent Fasting Induces Long-Lasting Gut Health and TOR-Independent Lifespan Extension. Curr Biol 28 (11), pp. 1714 - 1724 e4 (2018)

Collmann, F. M.; Pijnenburg, R.; Schneider, G.; Schafer, C.; Folz-Donahue, K.; Kukat, C.; Hoehn, M.: Imaging Reporter Strategy to Monitor Gene Activation of Microglia Polarisation States under Stimulation. J Neuroimmune Pharmacol 13 (3), pp. 371 - 382 (2018)

Donertas, H. M.; Fuentealba Valenzuela, M.; Partridge, L.; Thornton, J. M.: Gene Expression-Based Drug Repurposing to Target Ageing. Aging Cell, p. e12819 (2018)

Graef, M.: Membrane tethering by the autophagy ATG2A-WIPI4 complex. Proc Natl Acad Sci U S A 115 (42), pp. 10540 - 10541 (2018)

Graef, M.: Lipid droplet-mediated lipid and protein homeostasis in budding yeast. FEBS Lett (2018)