December 02, 2014
With the help of electron cryo-microscopy and a new technique for detecting electrons, they were able to elucidate the structure of the receptor with high accuracy. The animation shows how the protein changes its structure when calcium ions bind to it. Armed with this knowledge, scientists may be able to develop new materials in future to repair malfunctioning ryanodine receptors.
The ryanodine receptor forms a channel that is permeable for calcium ions. The animation illustrates how the protein changes its structure upon the binding of calcium. Four helical domains in the center form an ion gate, which allows solely calcium to pass. The so-called EF-hand is the sensor that recognizes the ions. The domain is also known from other calcium-sensing proteins. It consists of charged amino acids and opens the gate region when calcium is bound.