Scientific Publications

Borsellini, A.; Conti, D.; Cutts, E. E.; Harris, R. J.; Walstein, K.; Graziadei, A.; Cecatiello, V.; Aarts, T. F.; Ren, X.; Mazouzi, A. et al.; Sen, S.; Hoencamp, C.; Pleuger, R.; Ghetti, S.; Oberste-Lehn, L.; Pan, D.; Bange, T.; Haarhuis, J. H.; Perrakis, A.; Brummelkamp, T. R.; Rowland, B. D.; Musacchio, A.; Vannini, A.: Condensin II activation by M18BP1. Molecular Cell (2025)

Stradal, T. E.; Boiero Sanders, M.; Bieling, P.: Arp2/3-complex regulation - Novel insights and open questions. Current Opinion in Cell Biology (2025)

Führer , S.; Gallant, K.; Kaschani, F.; Kaiser, M.; Janning, P.; Waldmann, H.; Gersch, M.: Small Molecule-Induced Alterations of Protein Polyubiquitination Revealed by Mass-Spectrometric Ubiquitome Analysis. Angewandte Chemie, International Edition in English (2025)

Suruchi, S.; Ghetti, S.; Cmentowski, V.; Guerriere, T. B.; Stege, P.; Piano, V.; Musacchio, A.: Interplay of kinetochores and catalysts drives rapid assembly of the mitotic checkpoint complex. Nature Communications (2025)

Haque Kazi, N.; Klink, N.; Gallant, K.; Kipka, G.-M.; Gersch, M.: Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of the mitophagy regulator USP30. Nature Structural & Molecular Biology (2025)

Dudziak, A.; Pleuger, R.; Schmidt, J.; Hamm, F.; Tendulkar, S.; Jänen, K.; Vetter, I. R.; Singh, S.; Fischböck, J.; Herzog, F. et al.; Westermann, S.: The Spc105/Kre28 complex promotes mitotic error correction by outer kinetochore recruitment of Ipl1/Sli15. The EMBO Journal (2025)

Bukhdruker, S.; Gushchin, I.; Shevchenko, V.; Kovalev, K.; Polovinkin, V.; Tsybrov, F.; Astashkin, R.; Alekseev, A.; Mikhaylov, A.; Bukhalovich, S. et al.; Bratanov, D.; Ryzhykau, Y.; kuklina, D.; Caramello, N.; Rokitskaya, T.; Antonenko, Y.; Rulev, M.; Stoev, C.; Zabelskii, D.; Round, E.; Rogachev, A.; Borshchevskiy, V.; Ghai, R.; Bourenkov, G.; Zeghouf, M.; Chertfils, J.; Engelhard, M.; Chizhov, I.; Rodriguez-Valera, F.; Bamberg, E.; Gordeliy, V.: Proteorhodopsin insights into the molecular mechanism of vectorial proton transport. Science Advances (2025)

Fernkorn, M.; Schröter, C.: Med12 cooperates with multiple differentiation signals to facilitate efficient lineage transitions in embryonic stem cells. Journal of Cell Science (2025)

Hoock, J. G.; Burhop, A.; Greiner, L. C.; Schölermann, B.; Da Cruz Lopes Guita, C.; Liu, J.; Bag, S.; Pahl, A.; Sievers, S.; Scheel, R. et al.; Strohmann, C.; Ziegler, S.; Grigalunas, M.; Waldmann, H.: An Indole Dearomatization Strategy for the Synthesis of Pseudo-Natural Products. ChemBioChem: A European Journal of Chemical Biology (2025)

Armstrong , M. C.; Weiß, Y. R.; Hoachlander-Hobby, L. E.; Roy, A. A.; Visco, I.; Moe, A.; Golding, A. E.; Hansen, S. D.; Bement, W. M.; Bieling, P.: The biochemical mechanism of Rho GTPase membrane binding, activation and retention in activity patterning. The EMBO Journal (2025)

Schweighofer, J.; Mulay, B.; Hoffmann, I.; Vogt, D.; Pesenti, M.; Musacchio, A.: Interactions with multiple inner kinetochore proteins determine mitotic localization of FACT. Journal of Cell Biology (2025)

Binici, A.; Hennes, E.; Koska, S.; Niemann, J. A.; Reich, A.; Pfaff, C.; Sievers, S.; Kahtn, A. S.; Thomas, D.; Ziegler, S. et al.; Watzl, C.; Waldmann, H.: Identification of Natural Killer Cell Enhancers Through Mimicking of the Tumor Microenvironment. Chemistry (2025)

Griggs, S. D.; Piticari, A.-S.; Liver, S.; Arter, C.; Sievers, S.; Marsden, S. P.; Nelson, A.: Phenotype-directed discovery of diverse, biologically-relevant molecular scaffolds. Chemical Communications (2025)

Schulz, T.; Gontla, R.; Teuber, A.; Beerbaum, M.; Fletcher, B.; Mühlenberg, T.; Kaitsiotou, H.; Jardick, J.; Jeyakumar, K.; Keul, M. et al.; Müller, M.; Sievers, S.; Bauer, S.; Rauh, D.: Design, Synthesis, and SAR of Covalent KIT and PDGFRA Inhibitors─Exploring Their Potential in Targeting GIST. Journal of Medicinal Chemistry (2025)

Manik, M.; Pan, M.; Xiao, L.; Gu, W.; Kim, H.; Pospich, S.; Hedger, A.; Vajjhala, P.; Lee, M.; Qian, X. et al.; Landsberg, M.; Ve, T.; Nanson, J.; Raunser, S.; Stacey, K.; Wu, H.; Kobe, B.: Structural basis for TIR domain-mediated innate immune signaling by Toll-like receptor adaptors TRIF and TRAM. Proceedings of the National Academy of Sciences of the United States of America (2025)

Ng'ang'a, P. N.; Folz, J.; Kucher, S.; Roderer, D.; Xu, Y.; Sitsel, O.; Belyy, A.; Prumbaum, D.; Künemuth, R.; Assafa, T. et al.; Dong, M.; Seidel, C. A.; Raunser, S.: Multistate kinetics of the syringe-like injection mechanism of Tc toxins. Science Advances (2025)

Bauer, L. G.; Ward, J. A.; Díaz-Sáez , L.; Sundström, Y.; Tolvanen, T.; Alarcón Barrera, J. C.; Kostidis, S.; Rogers, C. M.; Panagakou, I.; Singh, U. et al.; Rothweiler, E. M.; Gonzalez Orta, A.; Kaniskan, H. Ü.; Hu, J.; Sievers, S.; Waldmann, H.; Giera, M.; Sundström, M.; Berg, L.; Huber, K.: Phenomics-based Discovery of Novel Orthosteric Choline Kinase Inhibitors. Angewandte Chemie, International Edition in English (2024)

Wendrich, K.; Gallant, K.; Recknagel, S.; Petroulia, S.; Haque Kazi, N.; Hane, J. A.; Führer, S.; Bezstarosti, K.; O'Dea, R.; Demmers, J. et al.; Gersch, M.: Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53. Nature Chemical Biology (2024)

Lim, W. M.; Chew, W.-X.; Esposito Verza, A.; Pesenti, M.; Musacchio, A.; Surrey, T.: Regulation of minimal spindle midzone organization by mitotic kinases. Nature Communications (2024)

Hedtfeld, M.; Musacchio, A.: Protocol for validating liquid-liquid phase separation as a driver of membraneless organelle assembly in vitro and in human cells. STAR Protoc. (2024)