Scientific Publications

Haase, M. A.; Lazar-Stefanita, L.; Baudry, L.; Wudzinska, A.; Zhou, X.; Rokas, A.; Hittinger, C. T.; Pfander, B.; Musacchio, A.; Boeke, J. D.: Ancient co-option of LTR retrotransposons as yeast centromeres. Nature (2026)

Greiner, L.; Bernal, F. A.; Thavam, S.; Brachthäuser, M.; Sievers, S.; Ziegler, S.; Waldmann, H.: Design, Synthesis, and Biological Evaluation of Pseudo-Natural Products Inspired by Aryloctahydroindole Alkaloids. ChemMedChem (2026)

Walstein, K.; Hill, L.; Vogt, D.; Oberste-Lehn, L.; Janning, P.; Vetter, I. R.; Pan, D.; Musacchio, A.: M18BP1 valency and a distributed interaction footprint determine epigenetic centromere specification in humans. The EMBO Journal (2026)

Zhang, R.; Liu, J.; Gasper, R.; Unger, A.; Kaschani, F.; Kaiser, M.; Janning, P.; Waldmann, H.: Covalent modification of a glutamic acid inspired by HaloTag technology. Nat Commun (2026)

Esposito-Verza, A.; Conti, D.; Pedroso, P. D. R.; Oberste-Lehn, L.; Körner, C.; Wohlgemuth, S.; Mansurkhodzhaev, A.; Vetter, I. R.; Pesenti, M.; Musacchio, A.: Molecular requirements for PLK1 activation by T-loop phosphorylation. The EMBO Journal (2026)

Müller, M.; Niemeyer, K.; Ojha, N. K.; Porav, S. A.; Vinayagam, D.; Urban, N.; Büchau, F.; Oleinikov, K.; Makke, M.; Bauer, C. C. et al.; Johnson, A. V.; Muench, S.; Zufall, F.; Bruns, D.; Schwarz, Y.; Raunser, S.; Leinders-Zufall, T.; Bon, R. S.; Schaefer, M.; Thorn-Seshold, O.: Ideal efficacy photoswitching for chromocontrol of TRPC4/5 channel functions in live tissues. Nature Chemical Biology (2026)

Hennes, E.; Lucas, B.; Scholes, N. S.; Cheng, X.-F.; Scott, D. C.; Bischoff, M.; Reich, K.; Gasper, R.; Lucas, M.; Xu, T. T. et al.; Rossini, S.; Pulvermacher, L.-M.; Dötsch, L.; Imrichova, H.; Brause, A.; Führer, S.; Naredla, K. R.; Sievers, S.; Kumar, K.; Janning, P.; Orabona, C.; Gersch, M.; Murray, P. J.; Schulmann, B. A.; Winter, G. E.; Ziegler, S.; Waldmann, H.: Monovalent pseudo-natural products supercharge degradation of IDO1 by its native E3 KLHDC3. Nature Chemistry (2026)

Engelhard , L.; Cakil, Z. V.; Zambrano-Mila, M.; Eppmann, S.; Gonzalez, T.; Linser, R.; Janning, P.; Becker, S.; Summerer, D.: Mammalian Proteome Profiling Reveals Readers and Antireaders of Strand-Symmetric and -Asymmetric 5-Hydroxymethylcytosine-Modifications in DNA. Advanced Science (2026)

Kremer, N.; Müller, F.; Nguyen, H.; Schulz, L.; Popp, T.; Artes, E.; Wolters, J.; Renner, M.; Vetter, I.; Maffini, S. et al.; Robles, M. S.; Musacchio, A.; Bange, T.: CUL4A-DDB1-DCAF10 is an N-recognin for N-terminally acetylated Src kinases. Nature Communications (2026)

Cheng, X.-F.; Belen, L.; Lampe, P.; Ugel, S.; Chen, S.; Unger, A.; Bischoff, M.; Rezaei Adariani, S.; Naredla, K. R.; Kumar, K. et al.; Schmidt, A.; Strohmann, C.; Janning, P.; Raphael, G.; Lucas, M.; Gersch, M.; Sievers, S.; Bronte, V.; Ziegler, S.; Waldmann, H.: Design, Synthesis, and Structural Evolution of Pseudo-Natural Product IDO1 Inhibitors and Degraders. Angewandte Chemie, International Edition in English (2025)

Shafaq-Zadah, M.; Dransart, E.; Hamitouche, I.; Wunder, C.; Chambon, V.; Valades-Cruz, C. A.; Leconte, L.; Kumar Sarangi, N.; Robinson, J.; Bai, S.-K. et al.; Regmi, R.; Di Cicco, A.; Hovasse, A.; Bartels, R.; Nilsson, U. J.; Cianferani-Sanglier, S.; Leffler, H.; Keyes, T. E.; Levy, D.; Raunser, S.; Roderer, D.; Johannes, L.: Spatial N-glycan rearrangement on α5β1 integrin nucleates galectin-3 oligomers to determine endocytic fate. Nature Communications (2025)

Moura, M.; Barbosa, J.; Leca, N.; Cunha-Silva, S.; Verza, A. E.; Pedroso, P. D.; Lemaire, S.; Duro, J.; Simoes-da-Silva, M.; Oliveira, A. et al.; Reis, R.; Nilsson, J.; Sunkel, C.; Musacchio, A.; Bollen, M.; Conde, C.: Polo kinase inhibits protein phosphatase 1 to promote the spindle assembly checkpoint and prevent aneuploidy. Current Biology (2025)

Biswas, A.; Greiner, L. C.; Bonowski, J.; Pahl, A.; Sievers, S.; Schmidt, A.; Strohmann, C.; Ziegler, S.; Grigalunas, M.; Waldmann, H.: Pseudo-Natural Products Inspired by Aspidospermidine-, Strychnos-, and Koumine Monoterpene Indole Alkaloids Reveal Pyrimidine Biosynthesis Inhibitors. Helvetica Chimica Acta (2025)

Perrier, M.; Loreth, D.; Brand, J.; Aubry, L.; Harrison, T.; Jacq, X.; Tate, E. W.; Kipka, G.-M.; Gersch, M.; Meyer-Schwesinger, C. et al.; Fauvarque, M.-O.; Bouron, A.: Deubiquitinating Enzyme UCH-L1 Regulates Neuronal Ca2+ Signaling. ACS Chemical Neuroscience (2025)

Shamloo, S.; Schloßhauer, J. L.; Tiwari, S.; Fischer, K. D.; Almolla, O.; Ghebrechristos, Y.; Kratzenberg, L.; Bejoy, A. M.; Aifantis, O.; Boccalatte, F. et al.; Wang, E.; Imig, J.: RNA binding of GAPDH controls transcript stability and protein translation in acute myeloid leukemia. RNA Biology (2025)

Oosterheert, W.; Boiero Sanders, M.; Hofnagel, O.; Bieling, P.; Raunser, S.: Choreography of rapid actin filament disassembly by coronin, cofilin, and AIP1. Cell (2025)

Ogel, E.; Becker, S.: Synthesis and Incorporation of a pH-Responsive Nucleoside Into DNA Sequences. ChemBioChem: A European Journal of Chemical Biology (2025)

Liu, Y.; Avathan Veettil, A.; Gasper, R.; Wagner, L.; Hastürk, O.; Wu, P.: Harnessing indole scaffolds to identify small-molecule IRE1α inhibitors modulating XBP1mRNA splicing. Nature Communications (2025)

Burn, G. L.; Raisch, T.; Tacke, S.; Winkler, M.; Prumbaum, D.; Thee, S.; Gimber, N.; Raunser, S.; Zychlinsky, A.: Myeloperoxidase transforms chromatin into neutrophil extracellular traps. Nature (2025)

Verena, C.; Musacchio, A.: The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona. Science Advances (2025)