Research report 2022 - Max Planck Institute of Immunobiology and Epigenetics
Anti-bacterial communication between cellular organelles
Max Planck Forschungsgruppe Organelle-Network Immunology
SummaryMacrophages are professional phagocytes equipped to efficiently capture and eliminate pathogens inside their internal digestive system, the phagolysosome. However, certain bacteria can resist the elimination inside macrophages and thus are able to escape the control of the immune system. Our research now identifies a specialized communication mode between two different organelles, the phagolysosome and the mitochondria, activating an effective and cell-intrinsic anti-bacterial defense mechanism to control bacterial growth.