Research report 2020 - Max Planck Institute for Infection Biology
More than a schematic: How we want to decipher immunological signaling pathways
Taylor, Marcus J.
Forschungsgruppe Visualisierung immunologischer Signalwege
SummaryCommunication is key for our immune system. When pathogens attack our body, this information must be passed on and converted into activity. We investigate the signalling mechanisms of the innate immune system to create a fundamental understanding of the function of these signal transduction pathways. To do so, we visualised the formation of the myddosome: a supramolecular organizing center, which forms at immune receptors and controls signal transmission. Our results can help understanding the dynamic interaction of signaling substances in immune cells.