Max Planck Institute for Terrestrial Microbiology

Max Planck Institute for Terrestrial Microbiology

The Institute's central task is to understand the way microorganisms work at the molecular, cellular and ecological level. Institute scientists are concerned, on the one hand, with getting to the bottom of the metabolic diversity of microorganisms. On the other hand, they analyse the mechanisms that enable microorganisms to adapt to changing environmental influences and to modify themselves accordingly. Furthermore, the scientists investigate how the organisms regulate their cell structure and their reproduction. They also study the biogeochemical processes responsible for the exchange of climatically-relevant trace gases. These analyses encompass all functional levels, from the atomic and structural level to the molecular and cellular level, through to biochemistry and physiology, microbial communities and the association of microorganisms with plants.


Karl-von-Frisch-Str. 10
35043 Marburg
Phone: +49 6421 178-0
Fax: +49 6421 178-999

PhD opportunities

This institute has an International Max Planck Research School (IMPRS):

IMPRS for Environmental, Cellular and Molecular Microbiology

In addition, there is the possibility of individual doctoral research. Please contact the directors or research group leaders at the Institute.

Social Networking at the Cellular Gateway

Researchers reveal nanoscale architecture of cellular uptake machinery

Signal transduction in cells: precise or economical?

A cellular signalling cascade balances information transmission against energy consumption

Environmentally friendly production of mandelic acid

Scientists found a method for the "green" production of the important starting material for the chemical industry

Light drives injection

By coupling a bacterial injection system with a light-controlled molecular switch, scientists are able to inject proteins into eukaryontic cells

“With MaxSynBio we are world class!”

Interview with Tobias Erb about artificial photosynthesis and the research network on synthetic biology


Metabolism 2.0

MaxPlanckResearch 1/2017 Environoment & Climate

Over 50 million genes and 40,000 proteins: combing through international databases for likely candidates, Tobias Erb and his colleagues at the Max Planck Institute for Terrestrial Microbiology in Marburg were faced with an overwhelming choice. In the end, the scientists picked out just 17 enzymes for the first synthetic metabolic pathway that is able to convert carbon dioxide into other organic molecules. Now they have to show that the cycle they sketched out on the drawing board also works in living cells.

Protecting the climate means also protecting the biotopes in which methane-oxidizing bacteria live.

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Insights into the inner life of living cells

2018 Endesfelder, Ulrike


Single-molecule localization microscopy offers unprecedented insights into living cells. In practice, however, many difficulties persist. By improving an important group of fluorophores, we were able to significantly reduce the damage the method causes in the imaged cells and to establish a novel, aberration-free multi-color strategy. This enables, among other things, the four-dimensional reconstruction of multi-protein-complexes such as the kinetochore in Schizosaccharomyces pombe.


The key enzymes of biological methane formation

2017 Shima, Seigo

Ecology Microbiology

Methane is an end product of anaerobic degradation of organic materials and is a potent greenhouse gas. Roughly, half of the world-wide methane emission is biologically performed by methanogenic archaea. We are interested in the enzymes involved in hydrogenotrophic methanogenesis. Here, we report on the crystal structure of the formyl-methanofuran dehydrogenase (Fwd) and heterodisulfide-reductase/hydrogenase complexes (Hdr/Mvh). These enzyme complexes are involved in the sequential reactions of ferredoxin reduction and CO2-reduction/fixation within the methanogenic pathway.


Synthetic carbon dioxide fixation

2016 Erb, Tobias

Ecology Genetics Microbiology

The conversion of the greenhouse gas carbon dioxide (CO2) into organic compounds is a key process in the global carbon cycle. In the past years, several novel pathways and enzymes for the conversion of CO2 were discovered in microorganisms. In parallel to these discoveries, new approaches were followed by using the methods of synthetic biology to establish artificial pathways for the fixation of CO2 that are more efficient compared to naturally existing CO2-fixation pathways. Synthetic CO2-fixation could pave the way towards novel applications in biotechnology and nanotechnology.


Architecture of bacterial communities

2015 Drescher, Knut

Developmental Biology Ecology Microbiology

Many bacterial species colonize surfaces and form dense three-dimensional structures, known as biofilms, which are resistant to antibiotics and constitute one of the major forms of bacterial biomass on Earth. The developmental process that gives rise to biofilms is largely unknown. It was recently discovered that between the initial surface attachment and mature tower-shaped biofilm structures, the cellular architecture undergoes several critical transitions.


How anaerobic bacteria and archaea conserve energy

2014 Buckel, Wolfgang


In clostridia the exergonic reduction of crotonyl-CoA to butyryl-CoA by NADH is coupled to the endergonic reduction of ferredoxin by NADH – a process called flavin-based electron bifurcation, catalyzed by a two-FAD-containing electron transferring flavoptrotein (Etf) and butyryl-CoA dehydrogenase (Bcd). This, and similar systems are wide-spread in anaerobic bacteria and archaea, which reduce ferredoxin for H2 formation in fermentations, for generation of ΔµNa+ via a ferredoxin-NAD reductase (Rnf) and in aceto-and methanogenesis for CO2 reduction by H2.

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