Research report 2018 - Max Planck Institute of Psychiatry

The uncharted territory of epitranscriptomics – mRNA modifications in psychiatric disorders

Stamp, Fabian; Binder, Elisabeth; Chen, Alon
Stress, Neurobiologie und Neurogenetik
Translationale Forschung in der Psychiatrie
Stress can affect gene expression through epigenetic mechanisms such as DNA-methylation. New research suggests a similar regulation at the level of messenger molecules (mRNA) which are responsible for the transmission of genetic information. The most common mRNA modification N6-methyladenosine (m6A) is regulated by stress in the brain and shows a changed signature in the blood of patients suffering from depression. Future research investigating the involvement of m6A in the stress response can provide a better understanding of the origin of stress-related psychiatric disorders.

For the full text, see the German version.

Go to Editor View