Research report 2014 - Max Planck Institute of Molecular Physiology
Elucidation of autophagy using novel chemical probes
Chemical Genomics Centre der Max-Planck-Gesellschaft
SummaryAutophagy is an important self-eating process in cells to eliminate or recycle cellular components or proteins out of use and takes place in cell organelles called autophagosomes. Development of autophagosome membranes involves complicated assemblies of lipids and proteins, highly regulated by a network of signals. Chemical probes including chemically modified proteins and small molecules enable researchers to elucidate the regulation mechanism of autophagy and molecular basis of autophagosome formation, previously not possible using traditional biochemical and cell biological approaches.