Yearbook 2013

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The "Long non-coding RNAs" (ncRNAs) research group is focusing on the molecular mechanisms of long non-coding RNAs. In particular, the scientists are studying how these transcripts are involved in transcriptional regulation and long-range gene activating functions. The goal is a better understanding of fundamental processes underlying regulation of gene expression. The detailed understanding of the complex class of ncRNAs is limited, however, their importance for gene regulation and disease progression is obvious, following studies in both basic science as well as clinical research. more
A mathematical analysis of human gene promoter sequences shows that these promoters fall into two distinct classes. A number of features correlate with these two classes, suggesting that this distinction is actually a reflection of different regulatory mechanisms. This article summarizes sequence features and biological properties specific for the promoters of the two classes. We explain how a mathematical analysis of whole-genome data could point towards particular biological mechanisms. more
For more than 25 years the German Climate Computing Center has been providing high performance computing platforms, data storage systems and related services exclusively and tailor-made to the German climate research. This lays the foundation for world-class climate science which is reflected in the contributions to the official symposium and the user workshop in February 2013 on the occasion of DKRZ’s anniversary. The following article will briefly review the exciting first 25 years of DKRZ. more
Together with the growing importance and mass of scientific data in the research process the management of the life cycle of scientific data becomes more and more important. This holds for the emerging of the data, for experiment data as well as for simulations, to the presentation of the data and to its long term availability. There is a growing need for a registration of these resources in the repositories, where the data stays unchanged, becoming referable and citeable. more
When solving Einstein's equations numerically, one faces the problem of treating an infinite asymptotically flat spacetime with finite computing resources. Here a decomposition of spacetime into hyperboloidal surfaces approaching lightlike infinity is considered. Upon compactification the Einstein equations develop formally singular terms, which can nevertheless be evaluated explicitly. Based on this method, stable numerical evolutions of spacetimes containing black holes and gravitational waves or matter fields have been achieved. more
Gravitational waves are predicted by the general theory of relativity. Binary systems consisting of neutron stars and black holes generate these tiny ripples in space-time, which are expected to be directly measured by large-scale interferometric detectors. Not only the measurement method, but also the data analysis is paramount for the first discoveries, since only sensitive and efficient methods can filter the weak signals from the detector noise. Scientists at the MPI for Gravitational Physics (Albert Einstein Institute) have helped to bring the first discoveries closer to reality. more
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