Research report 2012 - Max Planck Institute of Immunobiology and Epigenetics
Epigenetics: How male fruit flies compensate their missing X-chromosome
Akhtar, Asifa; Conrad, Thomas; Hallacli, Erinc
Abteilung für Chromatinregulierung
SummaryThe research focus of the Akhtar laboratory is to study epigenetic mechanisms underlying sex-specific X chromosomal gene regulation. The dosage compensation of the fruit fly (Drosophila melanogaster) constitutes a paradigm example of epigenetic regulation. In 2012, two important aspects of this mechanism were discovered: Firstly, important insights into the structure of the protein complex responsible for the dosage compensation were revealed and secondly the Akhtar lab could demonstrate the manner by which a protein complex in the nucleus influences the dosage compensation.