Research report 2005 - Max Planck Institute for Biophysical Chemistry
Cellular subtype identity in the pancreas
Molekulare Zellbiologie (Prof. Dr. Peter Gruss)
MPI für biophysikalische Chemie, Göttingen
SummaryA minor part of the pancreas is responsible for the secretion of hormones, such as insulin, to regulate the bloodsugar level. The mouse is used as an animal model to identify factors that drive the cellular subtype identity of these different hormone-producing cells. Two transcription factors Arx and Pax4 are required for the proper and coordinated development of these cells.