Scientific Publications

Wong, E. B.; Olivier, S.; Gunda, R.; Koole, O.; Surujdeen, A.; Gareta, D.; Munatsi, D.; Modise, T. H.; Dreyer, J.; Nxumalo, S. et al.; Smit, T. K.; Ording-Jespersen, G.; Mpofana, I. B.; Khan, K.; Sikhosana, Z. E. L.; Moodley, S.; Shen, Y.-J.; Khoza, T.; Mhlongo, N.; Bucibo, S.; Nyamande, K.; Baisley, K. J.; Cuadros, D.; Tanser, F.; Grant, A. D.; Herbst, K.; Seeley, J.; Hanekom, W. A.; Ndung'u, T.; Siedner, M. J.; Pillay, D.; Team, V.: Convergence of infectious and non-communicable disease epidemics in rural South Africa: a cross-sectional, population-based multimorbidity study. The Lancet Global Health 9 (7), pp. e967 - e976 (2021)

Jesson, J.; Dietrich, J.; Beksinska, M.; Closson, K.; Nduna, M.; Smit, J.; Brockman, M.; Ndung'u, T.; Gray, G.; Kaida, A.: Food insecurity and depression: a cross-sectional study of a multi-site urban youth cohort in Durban and Soweto, South Africa. TROPICAL MEDICINE & INTERNATIONAL HEALTH 26 (6), pp. 687 - 700 (2021)

Madhi, S. A.; Baillie, V.; Cutland, C. L.; Voysey, M.; Koen, A. L.; Fairlie, L.; Padayachee, S. D.; Dheda, K.; Barnabas, S. L.; Bhorat, Q. E. et al.; Briner, C.; Kwatra, G.; Ahmed, K.; Aley, P.; Bhikha, S.; Bhiman, J. N.; Bhorat, A. E.; du Plessis, J.; Esmail, A.; Groenewald, M.; Horne, E.; Hwa, S.-H.; Jose, A.; Lambe, T.; Laubscher, M.; Malahleha, M.; Masenya, M.; Masilela, M.; McKenzie, S.; Molapo, K.; Moultrie, A.; Oelofse, S.; Patel, F.; Pillay, S.; Rhead, S.; Rodel, H.; Rossouw, L.; Taoushanis, C.; Tegally, H.; Thombrayil, A.; van Eck, S.; Wibmer, C. K.; Durham, N. M.; Kelly, E. J.; Villafana, T. L.; Gilbert, S.; Pollard, A. J.; de Oliveira, T.; Moore, P. L.; Sigal, A.; Izu, A.; NGS-SA Group, . t. W.-V. C. G.: Efficacy of the ChAdOx1 nCoV-19 Covid-19 Vaccine against the B.1.351 Variant. The New England Journal of Medicine: NEJM / Publ. by the Massachusetts Medical Society 384 (20), pp. 1885 - 1898 (2021)

Wu, X.; Wu, Y.; Zheng, R.; Tang, F.; Qin, L.; Lai, D.; Zhang, L.; Chen, L.; Yan, B.; Yang, H. et al.; Wang, Y.; Li, F.; Zhang, J.; Wang, F.; Wang, L.; Cao, Y.; Ma, M.; Liu, Z.; Chen, J.; Huang, X.; Wang, J.; Jin, R.; Wang, P.; Sun, Q.; Sha, W.; Lyu, L.; Alves, P.; Dorhoi, A.; Pei, G.; Zhang, P.; Chen, J.; Gao, S.; Randow, F.; Zeng, G.; Chen, C.; Ye, X.-S.; Kaufmann, S. H. E.; Liu, H.; Ge, B.: Sensing of mycobacterial arabinogalactan by galectin-9 exacerbates mycobacterial infection. EMBO Reports, e51678 (2021)

Cele, S.; Gazy, I.; Jackson, L.; Hwa, S.-H.; Tegally, H.; Lustig, G.; Giandhari, J.; Pillay, S.; Wilkinson, E.; Naidoo, Y. et al.; Karim, F.; Ganga, Y.; Khan, K.; Bernstein, M.; Balazs, A. B.; Gosnell, B. I.; Hanekom, W.; Moosa, M.-Y. S.; Africa, N. f. G. S. i. S.; Team, C.-K.; Lessells, R. J.; de Oliveira, T.; Sigal, A.: Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma. Nature 593 (7857), pp. 142 - 146 (2021)

Farinre, O.; Gounder, K.; Reddy, T.; Tongo, M.; Hare, J.; Chaplin, B.; Gilmour, J.; Kanki, P.; Mann, J. K.; Ndung'u, T.: Subtype-specific differences in Gag-protease replication capacity of HIV-1 isolates from East and West Africa. Retrovirology 18 (1) (2021)

Singh, R.; Ramsuran, V.; Naranbhai, V.; Yende-Zuma, N.; Garrett, N.; Mlisana, K.; Dong, K. L.; Walker, B. D.; Karim, S. S. A.; Carrington, M. et al.; Ndung'u, T.: Epigenetic Regulation of BST-2 Expression Levels and the Effect on HIV-1 Pathogenesis. Frontiers in immunology 12, 669241 (2021)

Pei, G.; Zyla, J.; He, L.; Alves, P.; Steinle, H.; Saikali, P.; Lozza, L.; Nieuwenhuizen, N.; Weiner, J.; Mollenkopf, H.-J. et al.; Ellwanger, K.; Arnold, C.; Duan, M.; Dagil, Y.; Pashenkov, M.; Boneca, I. G.; Kufer, T. A.; Dorhoi, A.; Kaufmann, S. H. E.: Cellular stress promotes NOD1/2-dependent inflammation via the endogenous metabolite sphingosine-1-phosphate. EMBO Journal, e106272 (2021)

Garcia-Beltran, W. F.; Lam, E. C.; Denis, K. S.; Nitido, A. D.; Garcia, Z. H.; Hauser, B. M.; Feldman, J.; Pavlovic, M. N.; Gregory, D. J.; Poznansky, M. C. et al.; Sigal, A.; Schmidt, A. G.; Iafrate, A. J.; Naranbhai, V.; Balazs, A. B.: Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity. Cell 184 (9), pp. 2372 - 2383 (2021)

Rother, M.; Naumann, M.: Signal peptidase complex subunit 1 is an essential Zika virus host factor in placental trophoblasts. Virus Research 296, 198338 (2021)

Tegally, H.; Wilkinson, E.; Giovanetti, M.; Iranzadeh, A.; Fonseca, V.; Giandhari, J.; Doolabh, D.; Pillay, S.; San, E. J.; Msomi, N. et al.; Mlisana, K.; von Gottberg, A.; Walaza, S.; Allam, M.; Ismail, A.; Mohale, T.; Glass, A. J.; Engelbrecht, S.; Zyl, G. V.; Preiser, W.; Petruccione, F.; Sigal, A.; Hardie, D.; Marais, G.; Hsiao, N.-Y.; Korsman, S.; Davies, M.-A.; Tyers, L.; Mudau, I.; York, D.; Maslo, C.; Goedhals, D.; Abrahams, S.; Laguda-Akingba, O.; Alisoltani-Dehkordi, A.; Godzik, A.; Wibmer, C. K.; Sewell, B. T.; Lourenço, J.; Alcantara, L. C. J.; Pond, S. L. K.; Weaver, S.; Martin, D.; Lessells, R. J.; Bhiman, J. N.; Williamson, C.; de Oliveira, T.: Detection of a SARS-CoV-2 variant of concern in South Africa. Nature 592 (7854), pp. 438 - 443 (2021)

Heuberger, J.; Trimpert, J.; Vladimirova, D.; Goosmann, C.; Lin, M.; Schmuck, R.; Mollenkopf, H.-J.; Brinkmann, V.; Tacke, F.; Osterrieder, N. et al.; Sigal, M.: Epithelial response to IFN-γ promotes SARS-CoV-2 infection. Embo Molecular Medicine 13 (4), e13191 (2021)

Khuzwayo, S.; Mthembu, M.; Meermeier, E. W.; Prakadan, S. M.; Kazer, S. W.; Bassett, T.; Nyamande, K.; Khan, D. F.; Maharaj, P.; Mitha, M. et al.; Suleman, M.; Mhlane, Z.; Ramjit, D.; Karim, F.; Shalek, A. K.; Lewinsohn, D. M.; Ndung'u, T.; Wong, E. B.: MR1-Restricted MAIT Cells From The Human Lung Mucosal Surface Have Distinct Phenotypic, Functional, and Transcriptomic Features That Are Preserved in HIV Infection. Frontiers in immunology 12, 631410 (2021)

Beerens, D.; Franch-Arroyo, S.; Sullivan, T. J.; Goosmann, C.; Brinkmann, V.; Charpentier, E.: Survival Strategies of Streptococcus pyogenes in Response to Phage Infection. Viruses 13 (4) (2021)

Iftekhar, A.; Sigal, M.: Defence and adaptation mechanisms of the intestinal epithelium upon infection. Int J Med Microbiol 311 (3) (2021)

Lösslein, A. K.; Lohrmann, F.; Scheuermann, L.; Gharun, K.; Neuber, J.; Kolter, J.; Forde, A. J.; Kleimeyer, C.; Poh, Y. Y.; Mack, M. et al.; Triantafyllopoulou, A.; Dunlap, M. D.; Khader, S. A.; Seidl, M.; Hölscher, A.; Hölscher, C.; Guan, X. L.; Dorhoi, A.; Henneke, P.: Monocyte progenitors give rise to multinucleated giant cells. Nature Communications 12 (1) (2021)

Rother, M.; Dimmler, C.; Weege, F.; Mollenkopf, H.-J.; Meyer, T. F.; Naumann, M.: Discovery of Zika virus host dependency factors in trophoblasts using CRISPR/Cas9 screening. Journal of Virological Methods 290, 114085 (2021)

Leister, H.; Luu, M.; Staudenraus, D.; Krol, A. L.; Mollenkopf, H.-J.; Sharma, A.; Schmerer, N.; Schulte, L. N.; Bertrams, W.; Schmeck, B. et al.; Bosmann, M.; Steinhoff, U.; Visekruna, A.: Pro- and Antitumorigenic Capacity of Immunoproteasomes in Shaping the Tumor Microenvironment. Cancer Immunol Res 9 (6) (2021)

DiNardo, A. R.; Nishiguchi, T.; Grimm, S. L.; Schlesinger, L. S.; Graviss, E. A.; Cirillo, J. D.; Coarfa, C.; Mandalakas, A. M.; Heyckendorf, J.; Kaufmann, S. H. E. et al.; Lange, C.; Netea, M. G.; Crevel, a. R. V.: Tuberculosis endotypes to guide stratified host-directed therapy. Med 2 (3), pp. 217 - 232 (2021)

Müller, K.; Gibbins, M. P.; Roberts, M.; Reyes-Sandoval, A.; Hill, A. V. S.; Draper, S. J.; Matuschewski, K.; Silvie, O.; Hafalla, J. C. R.: Low immunogenicity of malaria pre-erythrocytic stages can be overcome by vaccination. Embo Molecular Medicine, e13390 (2021)