Evolutionary steps towards complex proteolytic machineries
Martin, Jörg; Lupas, Andrei N.
Controlled protein degradation plays a crucial role for the correct progression of cell cycle, signal transduction, gene expression or programmed cell death. In eukaryotes, organisms with a nucleus, a complex machinery of enzymes handles this highly regulated process. Recently, the existence of related enzyme systems has also been found in prokaryotes, organisms without a nucleus. The analysis of these nanomachines provides insight into the evolution of cellular protein degradation and the origin of the eukaryotic degradation machinery.
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