Research report 2019 - Max Planck Institute for Biology Tübingen

Evolutionary steps towards complex proteolytic machineries

Authors
Martin, Jörg; Lupas, Andrei N.
Departments
Abteilung Protein-Evolution
Summary
Controlled protein degradation plays a crucial role for the correct progression of cell cycle, signal transduction, gene expression or programmed cell death. In eukaryotes, organisms with a nucleus, a complex machinery of enzymes handles this highly regulated process. Recently, the existence of related enzyme systems has also been found in prokaryotes, organisms without a nucleus. The analysis of these nanomachines provides insight into the evolution of cellular protein degradation and the origin of the eukaryotic degradation machinery.

For the full text, see the German version.

Zur Redakteursansicht