Research report 2018 - Max Planck Institute for Biology of Ageing
Small protein modifications with high impact
Matić, Ivan; Colby, Thomas; Burkert, Annegret
Excellence-Cluster Cellular Stress Responses in Aging-Associated Diseases (CECAD)
SummaryADP-ribosylation (ADPr) is a protein modifier playing key roles in health and disease, from bacterial pathogenesis to cancer. Yet for decades it has been difficult to investigate the detailed mechanism of this modification. Using advanced proteomics, we discovered serine ADPr (Ser-ADPr) as a new and widespread protein marker needed for DNA damage response and were able to describe its biochemical basis by identifying its “writers” and “eraser”. These discoveries opened a large and novel research area into how ADPr regulates essential cellular processes.