Research report 2018 - Max Planck Institute of Molecular Cell Biology and Genetics
Uncovering Molecular Grammar
Hyman, Anthony; Alberti, Simon
Organization of cytoplasm
SummaryIn order to perform diverse functions, the cell`s proteins and RNAs are located in membraneous compartiments, but also as distinct condensates. Unexpectedly, recent advances show that the mechanisms by which condensates assemble may hold the key to explaining some of the biggest open questions in biology, paving the way for a revolution in our understanding of cellular physics. We have now uncovered a protein sequence encoded molecular grammar that underlies phase separation of some types of proteins inside cells.