Research report 2017 - Max Planck Institute for Molecular Biomedicine
Chromatin Architecture During Early Embryonic Development
Vaquerizas, Juan M.
Abteilung Regulatory Genomics
SummaryThe correct three-dimensional organisation of chromatin in the nucleus is a fundamental requirement for the proper functioning of the genome. As such, mutations in elements that determine this architecture lead to developmental disorders and cancer. In this work, chromatin conformation profiling in tightly staged Drosophila embryos revealed a dramatic reorganisation of chromatin that coincides with the zygotic genome activation.