Research report 2014 - Max Planck Institute for Terrestrial Microbiology
How anaerobic bacteria and archaea conserve energy
Max Planck Fellow; Mechanism of Enzymes from Anaerobic Bacteria
SummaryIn clostridia the exergonic reduction of crotonyl-CoA to butyryl-CoA by NADH is coupled to the endergonic reduction of ferredoxin by NADH – a process called flavin-based electron bifurcation, catalyzed by a two-FAD-containing electron transferring flavoptrotein (Etf) and butyryl-CoA dehydrogenase (Bcd). This, and similar systems are wide-spread in anaerobic bacteria and archaea, which reduce ferredoxin for H2 formation in fermentations, for generation of ΔµNa+ via a ferredoxin-NAD reductase (Rnf) and in aceto-and methanogenesis for CO2 reduction by H2.