Research report 2012 - Max Planck Institute of Biophysics
GcpE and LytB: Enzymes of isoprenoid biosynthesis as targets for drugs against malaria and tuberculosis
Rekittke, Ingo; Jomaa, Hassan; Ermler, Ulrich
SummaryIsoprenoids are involved in vital processes of all organisms. Their biosynthesis proceeds via two C5-building blocks, which are produced dependent on the organism either by the mevalonate- or the desoxyxylose (DOXP) pathway. The DOXP pathway is used by various human pathogens but not by man and therefore provides an attractive target for anti-infectious agents, e.g., against malaria and tuberculosis.