Research report 2009

cyclophilines and cancer

Schiene-Fischer, Cordelia

Hitzeschockproteine als enzymatische Faltungskatalysatoren (Dr. Cordelia Schiene-Fischer)
MPF für Enzymologie der Proteinfaltung, Halle/Saale

The human peptidyl-prolyl cis/trans isomerase (PPIase) cyclophilin A interacts with the tumor suppressor protein p53, whereas the highly related human cyclophilin B specifically interacts with the transcription factor Stat3. In vivo data suggest functional importance of both interactions observed. Thus, cyclophilin A and cyclophilin B both are involved, yet at different signaling levels, in cell signaling processes related to cancer development.

For the full text, see the German version.

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