Research report 2007 - Max Planck Institute for Developmental Biology

MicroRNAs - mighty dwarfs that switch off genes

Authors
Elisa Izaurralde
Departments

Abt. 2: Biochemie (Izaurralde)
MPI für Entwicklungsbiologie, Tübingen

Summary
MicroRNAs (miRNAs) are genome-encoded, about 22 nucleotide-long RNAs that silence gene expression post-transcriptionally by binding to 3’-untranslated regions of messenger RNAs. Although much information has been obtained about miRNA biogenesis and biological functions, the mechanisms allowing miRNAs to silence gene expression in animal cells remain controversial. Our goal is to understand the molecular mechanism of miRNA-mediated gene silencing.

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