Research report 2007 - Max Planck Institute for Developmental Biology
MicroRNAs - mighty dwarfs that switch off genes
Abt. 2: Biochemie (Izaurralde)
MPI für Entwicklungsbiologie, Tübingen
SummaryMicroRNAs (miRNAs) are genome-encoded, about 22 nucleotide-long RNAs that silence gene expression post-transcriptionally by binding to 3’-untranslated regions of messenger RNAs. Although much information has been obtained about miRNA biogenesis and biological functions, the mechanisms allowing miRNAs to silence gene expression in animal cells remain controversial. Our goal is to understand the molecular mechanism of miRNA-mediated gene silencing.