Research report 2019 - Max Planck Institute for Heart and Lung Research
Regulation of Notch signaling dynamics by deubiquitinating enzymes
Forschungsgruppe "Angiogenese und Metabolismus"
SummaryThe Notch signaling pathway is a highly conserved cell-cell communication mechanism that governs the development of and function of body tissues. We found that the enzyme USP10 is a novel regulator of this pathway, whose activity is particularly important for the growth of new blood vessels. Our studies revealed new insights into the molecular fundamentals of blood vessel development and could also have relevance for other physiological and pathological processes in which Notch signaling pathway plays a pivotal role.