Research report 2018 - Max Planck Institute for Metabolism Research
Obesity promotes the development of colorectal cancer
Abteilung "Obesity and Cancer"
SummaryObesity represents a major risk factor for colorectal cancer (CRC). Mouse studies demonstrate that the chronic low grade inflammation associated with obesity impairs intestinal insulin sensitivity and modulates the colorectal tumor microenvironment (TME), thus compromising the gut barrier and promoting CRC. These studies assign obesity-induced inflammation a critical role in the progression of CRC.