Research report 2017 - Max Planck Institute for Metabolism Research

Coordination of food intake, locomotion and sleep by the lateral hypothalamus

Korotkova, Tatiana
Max-Planck-Institut für Stoffwechselforschung, Köln
Coordination of food intake, locomotion and sleep is crucial for survival, its impairment is a symptom of multiple sleep and eating disorders. We found that optogenetic activation of GABA cells in the lateral hypothalamus leads to awakening from non-REM sleep and increases food intake. Further we characterized the neuronal circuit, which connects the prefrontal cortex and the lateral hypothalamus and utilizes gamma oscillations to organize function-selective firing of neurons and to promote food-seeking.

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