Research report 2018 - Max Planck Institute of Molecular Cell Biology and Genetics
The virtual liver
Zerial, Marino; Meyer, Kirstin; Ostrenko, Oleksandr; Bourantas, Georgios; Morales-Navarrete, Hernan; Porat-Shliom, Natalie; Segovia-Miranda, Fabian; Nonaka, Hidenori; Ghaemi,Ali; Verbavatz, Jean-Marc; Brusch, Lutz; Sbalzarini, Ivo F.; Kalaidzidis, Yannis; Weigert, Roberto
Max-Planck-Institut für molekulare Zellbiologie und Genetik, Dresden
SummaryResearchers of the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden developed a predictive 3D multi-scale model based on quantitative image analysis that stimulate the fluid dynamic properties of bile in the liver. This model can help to functionally characterize liver diseases, specific treatment options as well as drug-induced liver injury. Therefore, it is a promising tool for drug development to test and predict the effects of pharmacological compounds on the liver. The research team is now working on a strategy to calibrate this model to human biliary fluid dynamics.