Research report 2016 - Max Planck Institute for Infection Biology

Fountains of youth of the immune system

Melchers, Fritz
Senior Research Group Lymphocyte Development
For life, hematopoietic stem cells are springs of all new cells of the immune system. We have studied the embryonic origins of these stem cells, their migration from blood into fetal liver, their residence in bone marrow, their capacities to save energy and rest or to become active and differentiate into all types of mature cells of the immune system. Surprisingly, stem cells offer a home for quiescent, latent forms of tuberculosis bacteria. Thus, they may be a continuous danger for an eruption of active tuberculosis but may also be a source of continuously produced tuberculosis vaccine.

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