Research report 2015 - Fritz Haber Institute of the Max Planck Society
Structures of peptide aggregates investigated with the new Fritz Haber Institute free electron laser
von Helden, Gert; Schöllkopf, Wieland; Pagel, Kevin
„Molekülphysik” / „FEL Facility”
SummaryThe combination of several separation methods with the Fritz Haber Institute free electron laser has allowed to measure infrared spectra of size selected peptide-ion aggregates in the gas phase. The spectra reveal information on the peptides’ folding states, varying between helical and β-sheet. In the future, this approach of determining folding in peptide and protein aggregates can, potentially, contribute to the better understanding of protein misfolding, aggregation and the hereby caused diseases.