Yearbook 2015

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The folding of chromatin is an inherent property of the genome to incorporate the DNA in the cell nucleus. Recent advances using chromosome conformation capture technologies have shown that the genome is folded in structured domains, so-called TADs.  Structural variations, as they often occur in human genetic disease, can interfere with TAD configuration and thus result in altered gene expression and consecutive disease. By re-engineering human aberrations in mice it was shown that TADs and their boundaries are an essential component when interpreting structural variations. more
In 2015 DKRZ took its third high performance computing system for earth system research (HLRE-3) into operation. 41 million euros, funded by BMBF and HGF, enabled DKRZ to install the new energy-efficient PetaFLOPS supercomputer “Mistral”, to upgrade its HPSS archive system, as well as to adapt the datacenter's technical infrastructure to the new requirements. Mistral is installed in two phases: its first phase took up the operation in July. Its final stage, planned to be completed in summer 2016, will deliver three PetaFLOPs. In October, DKRZ and numerous guests officially inaugurated Mistral. more
Due to rapid technological progress bioinformatics becomes to be a key technology of molecular biology. Intensive statistical analysis of such high mounds of data requires considerable compute power and elaborate concepts of data handling like backup, storage and long-term archiving. Because local workgroups and IT divisions are mostly overstrained to carry this out, they need to be supported by computing centres. Internationalization of workflows in research projects requires encrypted pathways to transfer data and collaborating tools on save servers. A proven concept of support is given. more
The stability of solutions to Einstein’s equations is essential for the physical interpretation. However, its investigations are mathematically challenging. The Anti-de Sitter space (AdS) is a frequently used solution in theoretical physics, even though only recently insights about its stability were achieved. This article reviews the current state of research concerning that question, in particular the coexistence of stable and instable regimes. more

LISA Pathfinder paves the way for the detection of gravitational waves in space

Max Planck Institute for Gravitational Physics (Hannover) Reiche, Jens; Hewitson, Martin; Grothues, Hans-Georg; Knispel, Benjamin; Danzmann, Karsten
The LISA Pathfinder satellite mission demonstrates core technologies for future gravitational-wave observatories in space like eLISA. These observatories will study low-frequency gravitational waves, which are emitted by, e. g., binary supermassive black holes or galactic binary stars. LISA Pathfinder was launched on December 3, 2015, and has commenced its science operations in March 2016. LISA Pathfinder will lead to a comprehensive model of all significant physical noise sources that can be extrapolated to the eLISA mission. more
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