Research report 2014 - Max Planck Institute of Immunobiology and Epigenetics
Understanding why we’re fat, and why it matters
Lempradl, Adelheid; Pospisilik, Andrew
Department of Epigenetics
SummaryWorldwide, over two billion individuals are overweight and associated diseases including type-2-diabetes, stroke and cancer provide a major healthcare challenge. Our laboratory aims to understand mechanisms underlying obesity. Here, two recent studies are summarized; the first highlighting the identification of the enzyme HO-1 as a probable input separating healthy from metabolically diseased obesity, and the second, mapping the pathways allowing a father’s diet to control future offspring obesity susceptibility.