Research report 2003 - Max Planck Institute of Molecular Physiology
New Methods for the Combinatorial Solid Phase Synthesis of Compound Libraries
Authors
Breinbauer, Rolf; Gonthier, Elisabeth; Nad, Sukanya; Köhn, Maja; Niemeyer, Christof; Peters, Carsten; Waldmann, Herbert
Departments
Chemische Biologie (Prof. Dr. Herbert Waldmann)
MPI für molekulare Physiologie, Dortmund
Summary
The development of Organic Synthesis on Solid Phase (SPOS) allows the fabrication of a diverse set of organic molecules in a short time, which can function as potential ligands in biological screens. The scientists from MPI in Dortmund have been successful in implementing electroorganic reactions on solid phase, which adds a new class of reaction type to the methodological toolbox of SPOS. In addition they have established a new method for the fabrication of small molecule arrays which can be used in biological high-throughput-screening.