Molecular analysis of synaptic inhibition

The proper functioning of the nervous system requires a precise interplay of excitatory and inhibitory nerve impulses. Our department investigates the molecular mechanisms of synaptic inhibition in the central nervous system. A particular focus are studies on the function of membrane proteins which mediate or regulate inhibition by the amino acid glycine. By generating mouse mutants for specific subtypes of glycine transporters and glycine receptors, important functions of these proteins in the inhibition of motor and pain pathways could be identified. Our results are important for the development of new neuroactive drugs.