Research report 2012 - Max Planck Institute for Experimental Medicine
Regulation of axon growth
Authors
Kannan, Madhuvanthi; Schwedhelm-Domeyer, Nicola; Stegmüller, Judith
Departments
Arbeitsgruppe Molekulare und Zelluläre Neurobiologie
Summary
Axon growth is an essential event in the developing central nervous system. While a large body of evidence characterizes extrinsic mechanisms, there is little knowledge about intrinsic signaling pathways of axon growth regulation. The E3 ligase Cdh1-APC has been identified as a novel intrinsic inhibitor of axon growth. Thus, the research focuses on the elucidation of the Cdh1-APC signaling pathway.