Protein function and foldase catalysis

Foldases might assist slow folding and restructuring of proteins in the cell. However, the Alzheimer brain misses correct folding of several peptide and protein structures.  Already early folding intermediates might mediate toxic effects in the Alzheimer brain. The active site of a foldase is involved in the stabilization of the transition state of a folding chain. Does the simultaneous inhibition of this site by covalently linked inhibitors of two foldase families create new biochemical and biological properties? Data resulting from an animal model of Multiple Sclerosis support this idea.