Research report 2012 - Max Planck Institute of Biochemistry
The cell's molecular chaperones: their role in protein folding and in the development of neurodegenerative disorders
Hartl, F. Ulrich
SummaryProteins are synthesized as chains of amino acids. In order to fulfill a wide variety of biological functions, these chains must fold into specific three-dimensional patterns. This process of protein folding is mediated in our cells by molecular chaperones, helper molecules which act to prevent the clumping of faulty protein chains into aggregates. The formation of aggregates is the cause of neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease. Understanding the role of molecular chaperones will help in developing treatments for these and other diseases.