Research report 2011 - Max Planck Research Unit for Enzymology of Protein Folding

Control of protein functioning by catalyzed protein dynamics and protein aggregation

Authors
Fischer, Gunter
Departments
Enzymologie der Proteinfaltung (Prof. Dr. Gunter Fischer)
Summary
Both protein folding and biocatalysis are most important for life. A major aim of work of Max Planck researchers is to elucidate their interplay. Knowing whether or not chain dynamics play a key role for biocatalysis and misfolding diseases like Alzheimer´s and Parkinson´s is essential for avoiding malfunction of proteins in the cell. Their experiments are designed to characterize aggregation intermediates as well as folding-relevant Michaelis complexes. The methods allow for separate insight in chain dynamics during biocatalysis as well as in the formation of amyloid fibrils.

For the full text, see the German version.

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