Research report 2009 - Max Planck Institute of Molecular Physiology
Development of chemical probes in proteases research
Kaiser, Markus; Clerc, Jérôme; Hauske, Patrick; Mönig, Timon; Krahn, Daniel
Forschungsgruppe Kaiser - Chemical Genomics Centre
SummaryProteases are involved in countless biological processes. The application of selective small molecules for studying the biological function and regulation of proteases represents a promising alternative to established methods such as knock-out approaches. Here the development of such chemical tools from natural products and by rational design is reported with emphasis on progress in the application of the natural product syringolin as a proteasome inhibitor and the development of small molecule probes for HtrA proteases.