Research report 2006 - Max Planck Institute for Molecular Genetics
Mathematical models demonstrate the integration of information through cellular signal transduction pathways
Otto-Warburg-Laboratorium - Computational Systems Biology (Dr. Edda Klipp)
MPI für molekulare Genetik, Berlin
SummaryMolecular approaches reveal components and mechanisms of cellular stress sensing and adaptation. In addition, mathematical modeling has proven to foster the understanding of some basic principles of signal transduction and signal processing as well as of sensitivity and robustness of information perception and cellular response. Main modeling principles are exemplified here for a model organism, the yeast Saccharomyces cerevisiae.