Yearbook 2011

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For more than 15 years, genome research has looked for clinically relevant genetic risk factors for common diseases, with meagre results. Now rare disorders come into focus of genome research worldwide. Scientists at the Department of Human Molecular Genetics have successfully dealt with rare genetic disorders for many years. Since the introduction of novel, affordable sequencing techniques it has become possible, in principle, to elucidate the molecular causes of all single gene disorders, with far-reaching consequences for diagnosis, prevention and therapy. more
The scientific focus of the research group lies on the systematic analysis of the modulation of gene and protein expression. This process can be specifically influenced by the interaction of genes and natural products, which are e.g. derived from food. We analyse if and by which mechanisms natural products interfere with genes or gene products. The interdisciplinary approach comprises basic and applied research. The results can be useful for optimised application of natural products to improve various metabolic processes. more

ScalES - Scalable Earth-System-Models

German Climate Computation Center Jörg Behrens, Joachim Biercamp, Thomas Jahns, Jana Meyer
The ScalES project addressed typical scaling problems of coupled earth system models. Scientists from DKRZ (also coordination), Alfred-Wegener-Institute for Polar and Marin Research, IBM Germany, Max Planck Institute for Chemistry, Max Planck Institute for Meteorology and Karlsruher Institute for Technology cooperated in creating software libraries of general use for improving the scaling of earth system models and beyond. Major components are parallel IO, partitioning and parallelization module, and global communication (UniTrans). more
The ever-increasing flood of data in the scientific realm is a constant challenge for storage concepts. This article describes the GWDG's storage network and global file system with integrated tape archiving. This combination makes it possible to provide the institutes with fast, fail-safe storage, that can be expanded at any time, implemented using up-to-date technology. more
There are currently two theories that can explain both the homogeneity of the universe and the temperature fluctuations in the cosmic background radiation: inflation and the cyclic universe. Both models however lead to different predictions regarding the fine details of the distributions of these temperature fluctuations, so that upcoming data will be able to distinguish between them. According to string theory, both types of universe should be physically realised. This begs the question of whether one can already predict on a theoretical level which type of universe we are likely to inhabit. more
Pulsars are rapidly rotating, highly magnetized neutron stars which act as cosmic lighthouses by flashing at radio, X-ray or gamma-ray wavelengths. The search for gamma-ray-only pulsars is extremely difficult and computing-intensive. Even high-tech telescopes, like the one aboard the Fermi satellite, register only a few gamma-ray photons per day from such a pulsar. Using a more efficient analysis method, originally developed for detection of gravitational waves from these fast spinning neutron stars, a number of previously unknown gamma-ray pulsars have been discovered in the Fermi data. more
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