Research report 2007 - Max Planck Institute for the Physics of Complex Systems
Transcriptional pausing of RNA polymerase II
Motor Systeme ()
MPI für Physik komplexer Systeme, Dresden
SummaryTo make the proteins in all of our cells, the genetic information that is stored in DNA is first copied to mRNA and then translated to the polypeptide chain. RNA polymerase II is responsible fort the first step, and it proceeds in a discontinuous fashion with about half of its time spent in pauses. Experimental and theoretical studies on single molecules of RNAP II identify a pause state that proceeds as a random walk, which can generate pauses of durations that bridge scales of time.