Research report 2006 - Max Planck Institute for Brain Research

Signals from target organs control the differentiation of neurons

Rohrer, Hermann

Entwicklungsneurobiologie (apl. Prof. Dr. Hermann Rohrer)
MPI für Hirnforschung, Frankfurt/Main

Nervous system development depends on mechanisms that control the generation of different neuronal subtypes. In the peripheral nervous system, signals from innervated targets elicit the specialization to different functional neuronal subtypes. The target-dependent cholinergic differentiation of sympathetic neurons is mediated in vivo by members of the gp130-cytokine family.

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