Research report 2008 - Max Planck Institute for Infection Biology
Lymphocyte development from stem cells
Lymphozytenentwicklung (Melchers) (Prof. Dr. Dr. h. c. Fritz Melchers)
MPI für Infektionsbiologie, Berlin
SummaryAll essential blood forming cells can be generated from the embryonic stem cells of mice and retransplanted into recipient mice. The influence of a larger number of genes with different functions during the generation of the innate and adaptive immune system can thus genetically be studied under natural conditions. Since in embryonic stem cells a defect gene can be replaced by a copy of its intact form by homologous recombination, immunodeficiencies can be repaired by targeted gene therapy.