Born on October 15, 1943 in Steinkirchen, Lower Saxony. Study of medicine in Freiburg and Munich (1965-1970), scientific staff member at the Institute for Human Genetics Freiburg Univ. (1971), Dr. med. (1973), German Habilitation in human genetics (1978), Associate Professor Freiburg Univ. (1981), Full Professor and head of the Dept. of Human Genetics Nijmegen Univ. (1984-1997), specialisation in clinical genetics (1987), Director and Scientific Member at the Max Planck Institute for Molecular Genetics (since 1994), Honorary Professor for Human Genetics at Humboldt University, Berlin.